F4883
Fibrinogeno
35-65% protein (≥90% of protein is clottable).
Sinonimo/i:
Fattore I
Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
About This Item
Prodotti consigliati
Origine biologica
human plasma
Livello qualitativo
Descrizione
essentially plasmin(ogen) free
Forma fisica
powder
Qualità
35-65% protein (≥90% of protein is clottable).
PM
α-chain 63.5 kDa
β-chain 56 kDa
γ chain 47 kDa (about 4% carbohydrate content)
soluble dimer 340 kDa
Concentrazione
35-65% protein (biuret)
tecniche
cell culture | mammalian: suitable
Solubilità
0.9% NaCl: soluble
Temperatura di conservazione
−20°C
Cerchi prodotti simili? Visita Guida al confronto tra prodotti
Descrizione generale
Fibrinogen was the first blood coagulation factor to be identified, and it is a precursor of fibrin protein. This protein is composed of two chains, each of which is composed of three chains- α, β and γ. These three subunits are coded by three genes located in the human chromosomal locus 4q23-q32, and spans 51kb.
Applicazioni
Fibrinogen from human plasma has been used for-
- fibrinogen adsorption assay performed on swCNTs (single-walled carbon nanotubes)
- the characterization of fibrinogen structure in the presence of CNT using CD (Circular dichroism) spectroscopy and temperature scan
- the preparation of RBC suspension obtained from venous blood of antecubital vein, to assess RBC aggregability
- fibrinolysis assay performed on mouse embryonic fibroblasts (MEFs)
- the preparation of fibrinogen-labeled gold (Fgn/Au)
- the quantification of in vitro angiogenesis by human microvascular endothelial cells and
- the assessment of fibrin-induced apoptosis and differentiation-regulation in trophoblast obtained from term human placentas.
Azioni biochim/fisiol
Il fibrinogeno è una proteina della fase acuta che fa parte delle proteine della cascata della coagulazione. Il risultato finale della cascata è la produzione di trombina che converte il fibrinogeno in fibrina. La trombina proteolizza rapidamente il fibrinogeno con rilascio del fibrinopeptide A. La perdita di questo piccolo peptide non è sufficiente a rendere insolubile la molecola di fibrina risultante ma tende a formare complessi con molecole di fibrina e fibrinogeno adiacenti. La trombina poi scinde un secondo peptide, il fibrinopeptide B, dalla fibrina e i monomeri di fibrina creati polimerizzano in seguito spontaneamente formando un gel insolubile. La fibrina polimerizzata è tenuta insieme da forze non covalenti ed elettrostatiche ed è stabilizzata dall′enzima transamidante, fattore XIIIa, che è prodotto dall′azione della trombina sul fattore XIII. Gli aggregati insolubili di trombina (coaguli) e le piastrine aggregate bloccano poi il vaso danneggiato e impediscono l′ulteriore sanguinamento. La quantità di fibrinogeno nel plasma può servire da indicatore aspecifico della eventuale presenza di un processo infiammatorio nell′organismo. Il fibrinogeno originato da qualsiasi mammifero sarà scisso dalla trombina di qualsiasi mammifero.
Fibrinogen is an acute-phase inflammatory protein, which plays an essential role in blood clotting. Coronary heart disease is linked to the plasma levels of fibrinogen in Chinese population, and might have potential as a marker and risk factor for the same. A -455 allele of fibrinogen β (FGB) chain is linked with poor survival in Caucasian women with Finnish stroke. Ischemic stroke preceded by hyperfibrinogenemia has poor outcome, which is independent of the baseline fibrinogen concentration.
Specifiche
Source material has tested negative for HIV and HBsAg.
Stato fisico
Lyophilized powder containing sodium citrate and sodium chloride.
Risultati analitici
Protein determined by biuret
Esclusione di responsabilità
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
I clienti hanno visto anche
Marta Swarowska et al.
Inflammation, 37(4), 1142-1147 (2014-02-18)
Hyperfibrinogenemia at the beginning of ischemic stroke is associated with poor outcome. We hypothesized that the sustained increase of plasma fibrinogen during stroke predicts outcome independently of baseline fibrinogen concentration. We included 266 patients with first-ever ischemic stroke in whom
Bin Song et al.
International journal of clinical and experimental medicine, 8(8), 13195-13202 (2015-11-10)
Coronary heart disease (CHD) remains the leading causes of death and disability for men and women in most developed countries. It may soon become the leading cause of death in developing countries. Several studies have examined the role of fibrinogen
J G White
The American journal of pathology, 137(4), 989-998 (1990-10-01)
Glycoprotein (GP)IIb-IIIa receptors on human platelets in suspension and after surface activation bind a variety of specific antibodies and ligands and transport them across the outside of the plasma membrane by processes of clustering, patching and capping, and endocytosis to
A synergistic effect of albumin and fibrinogen on immunoglobulin-induced red blood cell aggregation.
Ronen Ben-Ami et al.
American journal of physiology. Heart and circulatory physiology, 285(6), H2663-H2669 (2003-07-19)
Therapeutic administration of immunoglobulins (Ig) has the potential to precipitate thrombotic events. This phenomenon may be explained by red blood cell (RBC) aggregation, which can be potentiated by Ig. The contribution of plasma albumin and fibrinogen to Ig-induced RBC aggregation
Sung Jean Park et al.
International journal of nanomedicine, 7, 4325-4333 (2012-08-24)
The conformational changes of plasma protein structures in response to carbon nanotubes are critical for determining the nanotoxicity and blood coagulation effects of carbon nanotubes. In this study, we identified that the functional intensity of carboxyl groups on carbon nanotubes
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica.