G117

Glipizide

solid

• Sinonimo/i: 1-Cyclohexyl-3-{4-[2-(5-methylpyrazine-2-carboxamido)ethyl]phenylsulfonyl}urea
• Formula empirica (notazione di Hill): C₂₁H₂₇N₅O₄S
• Numero CAS: 29094-61-9
• Peso molecolare: 445.54
• Numero CE: 249-427-6
• Numero MDL: MFCD00072159
• Codice UNSPSC: 12352200
• ID PubChem: 24277839
• NACRES: NA.77

Proprietà

• Stato: solid
• Livello qualitativo: 100
• Colore: white
• Solubilità: methanol: 1.9 mg/mL; DMSO: 48 mg/mL
• Stringa SMILE: Cc1cnc(cn1)C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3
• InChI: 1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28); ZJJXGWJIGJFDTL-UHFFFAOYSA-N
• Informazioni sul gene: human ... ABCC8(6833) , KCNJ1(3758) , KCNJ11(3767)

Descrizione

Descrizione generale

Potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1) codes for a renal outer medullary potassium channel (ROMK1, Kir1.1). Glipizide is an antidiabetic drug, that is used to treat type II diabetes.(5)

Applicazioni

Glipizide has been used in:

• chick embryo yolk sac membrane (YSM) and chorioallantoic membrane (CAM) assay
• MCF-7 breast cancer assay on chorioallantoic membrane (CAM)
• metastasis assays
• rat aortic ring assay
• in vivo matrigel plug assay
• 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay
• flow cytometry
• western blotting

Azioni biochim/fisiol

Potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1) plays a vital role in potassium balance. It is an ATP-dependent K⁺ channel blocker. The encoded protein is liable for the elimination of potassium in exchange for the absorption of sodium by the epithelial sodium channel (ENaC). Mutation in KCNJ1 is linked with several diseases, such as, antenatal Bartter syndrome and diabetes. Glipizide helps to repress the development of tumors and metastasis by preventing angiogenesis.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)