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Merck
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Key Documents

F8932

Sigma-Aldrich

Fatostatin hydrobromide

≥98% (HPLC), powder

Sinonimo/i:

25B11 hydrobromide, 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propylpyridine hydrobromide, Fatostatin A hydrobromide; 2-(2-propylpyridin-4-yl)-4-p-tolylthiazole hydrobromide

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About This Item

Formula empirica (notazione di Hill):
C18H18N2S·HBr
Numero CAS:
298197-04-3
Peso molecolare:
375.33
Codice UNSPSC:
12352200
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

powder

Condizioni di stoccaggio

desiccated

Colore

light yellow to yellow

Solubilità

DMSO: ≥10 mg/mL

Temperatura di conservazione

2-8°C

InChI

1S/C18H18N2S.BrH/c1-3-4-16-11-15(9-10-19-16)18-20-17(12-21-18)14-7-5-13(2)6-8-14;/h5-12H,3-4H2,1-2H3;1H
RJCFNQZVFUMORB-UHFFFAOYSA-N

Descrizione generale

Fatostatin is a non-sterol diarylthiazole derivative. It prevents insulin-induced adipogenesis and lowers the amounts of fatty acid, triglyceride and low-density lipoprotein. Fatostatin has anti tumor and antimitotic properties.

Applicazioni

Fatostatin hydrobromide has been used:
  • to study its anti-cancer activity and effects on mitotic microtubule spindle
  • to study its effects on stomatal development
  • to prevent SREBP cleavage-activating protein (SCAP)-mediated escort of sterol regulatory element-binding proteins (SREBPs)

Azioni biochim/fisiol

Fatostatin hydrobromide is an SREBP inhibitor. Fatostatin hydrobromide inhibits fat production and lowers glucose levels in mice by inhibiting SREBP (Sterol Regulatory Element Binding Proteins).

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Inhibition of cell polarity establishment in stomatal asymmetric cell division using the chemical compound bubblin
Sakai Y, et al.
Development, dev-145458 (2017)
Fatostatin displays high antitumor activity in prostate cancer by blocking SREBP-regulated metabolic pathways and androgen receptor signaling
Li X, et al.
Molecular Cancer Therapeutics, 13(4), 855-866 (2014)
Yumiko Sakai et al.
Development (Cambridge, England), 144(3), 499-506 (2017-01-15)
Stem cell polarization is a crucial step in asymmetric cell division, which is a universal system for generating cellular diversity in multicellular organisms. Several conventional genetics studies have attempted to elucidate the mechanisms underlying cell polarization in plants, but it
Chih-Ming Huang et al.
Cells, 9(1) (2019-12-22)
: Elevated activity of sterol regulatory element-binding protein 1 (SREBP1) has been implicated in the tumorigenesis of different cancer types. However, the functional roles of SREBP1 in esophageal cancer are not well appreciated. Here, we aimed to investigate the therapeutic
Fatostatin inhibits cancer cell proliferation by affecting mitotic microtubule spindle assembly and cell division.
Gholkar A A, et al.
The Journal of Biological Chemistry, 291(33), 17001-17008 (2016)
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