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F2379

Sigma-Aldrich

Fetuin from fetal bovine serum

lyophilized powder, suitable for cell culture

Sinonimo/i:

Fetuin from fetal calf serum

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About This Item

Numero CAS:
9014-81-7
Numero CE:
232-762-7
Numero MDL:
MFCD00131055
Codice UNSPSC:
12352202
NACRES:
NA.61

Origine biologica

bovine serum (fetal)

Forma fisica

lyophilized powder

tecniche

cell culture | mammalian: suitable

Impurezze

≤0.3% free N-acetylneuraminic acid

Solubilità

H2O: 1 mg/mL, colorless to faint yellow or tan

N° accesso UniProt

Q58D62

Temperatura di conservazione

2-8°C

Informazioni sul gene

bovine ... FETUB(504615)

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Descrizione generale

Fetuin from fetal bovine serum is a 64 kDa plasma glycoprotein. It is produced by the liver and adipose tissue.

Applicazioni

Fetuin from fetal bovine serum has been used:
  • to synthesize primary and secondary calciprotein particles (CPP)
  • to study the binding of Xerocomus chrysenteron lectin (XCL) to the T antigen expressed by membrane proteins
  • as a supplement in Ham′s F10 media for myoblast culture.

Fetuin is a protein with the ability to bind to the insulin receptor and inhibit insulin action. Fetuin has been used in studies of type 2 diabetes mellitus (T2DM). In patients with T2DM, fetuin has been shown to be significantly lower when compared to control patients. Fetuin has also been used in studies to demonstrate its protective role in the development of arterial calcification.

Azioni biochim/fisiol

Fetuin, an inhibitor of insulin receptor tyrosine kinase, modulates bone remodeling and calcium metabolism. It is involved in keratinocytes migration and breast tumor cell proliferative signaling. Fetuin also regulates vascular calcification, insulin resistance and protease activity It acts as a biomarker for neurodegenerative diseases. Fetuin has anti-inflammatory property.

Nota sulla preparazione

Prepared by ammonium sulfate fractionation of fetal bovine serum by the method of Pederson, K.O., J. Phys. and Colloid Chem., 51, 164 (1947).

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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