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E6530

Sigma-Aldrich

Etomidate

>98% (HPLC), powder

Sinonimo/i:

(R)-1-(α-Methylbenzyl)imidazole-5-carboxylic acid ethyl ester, Amidate, R16659

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About This Item

Formula empirica (notazione di Hill):
C14H16N2O2
Numero CAS:
33125-97-2
Peso molecolare:
244.29
Numero CE:
251-385-9
Numero MDL:
MFCD00869295
Codice UNSPSC:
12352200
ID PubChem:
24894630
NACRES:
NA.77

Saggio

>98% (HPLC)

Forma fisica

powder

Colore

white

Solubilità

DMSO: >10 mg/mL

Ideatore

Johnson & Johnson

Temperatura di conservazione

2-8°C

Stringa SMILE

CCOC(=O)c1cncn1[C@H](C)c2ccccc2

InChI

1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1
NPUKDXXFDDZOKR-LLVKDONJSA-N

Informazioni sul gene

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

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Descrizione generale

Etomidate is an imidazole derivative, which functions as an nonbarbiturate hypnotic agent. It is used in speech and memory test. Etomidate regulates hemodynamic stability by preserving sympathetic outflow and autonomic reflexes. It inhibits adrenal steroidogenesis.

Azioni biochim/fisiol

Etomidate is a general anesthetic; potentiates GABAA transmission. The possible neuroprotective effect of etomidate against streptozotocin-induced (STZ-induced) hyperglycaemia were investigated in the rat brain and spinal cord. Etomidate treatment demonstrated neuroprotective effect on the neuronal tissue against the diabetic oxidative damage

Caratteristiche e vantaggi

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pittogrammi

Exclamation markEnvironment
GHS07,GHS09

Avvertenze

Warning

Indicazioni di pericolo

H302,H410

Consigli di prudenza

P273 - P301 + P312 + P330

Classi di pericolo

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

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E Domínguez et al.
Placenta, 34(9), 738-744 (2013-07-10)
Umbilical artery (UA) hemodynamics reflect blood flow and vascular resistance in the placental circulation. We examined non-invasively the hemodynamic effects of propofol, etomidate, and alphaxalone on the placental circulation of a sheep model by means of UA Doppler ultrasonography. Eleven
Sympathetic responses to induction of anesthesia in humans with propofol or etomidate.
Ebert TJ, et al.
Anesthesiology, 76(5), 725-733 (1992)
Beatrice de la Grandville et al.
European journal of anaesthesiology, 29(11), 511-514 (2012-09-12)
Etomidate is an imidazole-derived hypnotic agent preferentially used for rapid sequence induction of anaesthesia because of its favourable haemodynamic profile. However, 11β-hydroxylase inhibition causes adrenal insufficiency with potentially fatal consequences in specific populations. We review the arguments against the liberal
Etomidate speech and memory test (eSAM) A new drug and improved intracarotid procedure
Jones-Gotman M, et al.
Neurology, 65(11), 1723-1729 (2005)
A Möller Petrun et al.
British journal of anaesthesia, 110(3), 388-396 (2012-11-21)
In a double-blind, randomized trial, we compared the haemodynamic effects of a bispectral index (BIS)-guided etomidate and propofol infusion for anaesthesia induction in patients undergoing major abdominal surgery. Forty-six patients were randomly assigned to two groups based on the induction
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