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D1068

Sigma-Aldrich

DCB

≥98% (HPLC), solid

Sinonimo/i:

3,3′-Dichlorobenzaldazine, NSC 67224

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About This Item

Formula empirica (notazione di Hill):
C14H10Cl2N2
Numero CAS:
6971-97-7
Peso molecolare:
277.15
Numero MDL:
MFCD00556081
Codice UNSPSC:
12352200
ID PubChem:
24724458
NACRES:
NA.77

Saggio

≥98% (HPLC)

Forma fisica

solid

Condizioni di stoccaggio

desiccated
under inert gas

Colore

yellow

Solubilità

DMSO: ~6.8 mg/mL
H2O: insoluble

Temperatura di conservazione

2-8°C

Stringa SMILE

Clc1cccc(\C=N\N=C\c2cccc(Cl)c2)c1

InChI

1S/C14H10Cl2N2/c15-13-5-1-3-11(7-13)9-17-18-10-12-4-2-6-14(16)8-12/h1-10H/b17-9+,18-10+
XMOVWXSCYLINBJ-BEQMOXJMSA-N

Azioni biochim/fisiol

3,3′-dichlorobenzaldazine (DCB) serves as an allosteric ligand with neutral cooperativity. It helps to block the positive allosteric regulation of mGluRs (metabotropic glutamate receptor subtype 5 (mGluR5) with the help of 3,3′-difluorobenzaldazine (DFB) and the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB).
Neutral allosteric modulator of the metabotropic glutamate receptor mGluR5.

Caratteristiche e vantaggi

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Avvertenze

Danger

Indicazioni di pericolo

H302,H315,H317,H318,H335,H410

Classi di pericolo

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificati d'analisi (COA)

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