C6348

Monoclonal Anti-CXCR2 (IL-8 RB) antibody produced in mouse

clone 48311.211, purified immunoglobulin, lyophilized powder

• Numero MDL: MFCD01864633
• Codice UNSPSC: 51111800
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Coniugato: unconjugated
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: 48311.211, monoclonal
• Forma fisica: lyophilized powder
• Reattività contro le specie: human
• tecniche: flow cytometry: suitable; neutralization: suitable
• Isotipo: IgG2a
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... IL8RB(3579) ; mouse ... Il8rb(12765)

Descrizione

Descrizione generale

The antibody will neutralize human cell surface CXCR-2 mediated-myloperoxidase release from human granulocytes induced by GROα. It will not block myeloperoxidase release induced by IL-8. The antibody reacts with human CXCR-2 transfectant cells and not the parent cell line. The antibody shows no cross-reactivity with CXCR-1.

Immunogeno

human CXCR2 transfected NSO mouse myeloma cells.

Azioni biochim/fisiol

CXCR2 is a G protein-coupled receptor that binds IL-8 with high affinity. It mediates migration of neutrophils to the sites of inflammation. It also binds CXCL1 and stimulates growth of melanomas.

Stato fisico

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Nota sulla preparazione

Purified using protein G.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)