C4749
Carboxylesterase 2 human
recombinant, expressed in mouse NSO cells, ≥95% (SDS-PAGE)
Sinonimo/i:
CES2, CES2A1
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About This Item
Prodotti consigliati
Ricombinante
expressed in mouse NSO cells
Livello qualitativo
Saggio
≥95% (SDS-PAGE)
Forma fisica
solution
Attività specifica
≥1.0 EU/μg
30,000 pmol/min-μg protein
PM
predicted mol wt ~60 kDa
Concentrazione
0.4-0.6 mg/mL
Impurezze
≤1.0 EU/μg endotoxin
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
Informazioni sul gene
human ... CES2(8824)
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Azioni biochim/fisiol
Human carboxylesterase 2 (hCE-2) recognizes a substrate with a large alcohol group and small acyl group. Its substrate specificity may be restricted by a capability of acyl-hCE-2 conjugate formation due to the presence of conformational interference in the active site pocket. Carboxylesterases catalyze the biotransformation of several ester-containing drugs and prodrugs such as angiotensin-converting enzyme inhibitor (temocarpil, cilazapril), anti-tumor drugs (capecitabin) and narcotics.
Member of a serine esterase family that hydrolyze ester and amide bonds. Carboxylesterase 2 is an endoplasmic reticulum-bound hydrolase that plays a critical role in xenobiotic detoxification and activation for ester-containing therapeutics. Carboxylesterase 2 is also involved in the detoxification of drugs such as heroin and cocaine. This enzyme is thought to play a role in lipid metabolism.
Definizione di unità
One unit will cause the hydrolysis of 1 picomole of p-nitrophenylacetate per minute at pH 7.5 at 25 deg C.
Stato fisico
Supplied as a solution containing sodium chloride, sodium acetate, and 20% glycerol.
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Resp. Sens. 1
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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