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Key Documents

C4650

Sigma-Aldrich

Cholestyramine resin

Sinonimo/i:

Colestyramine, Dowex 1X2 Cl--Form

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About This Item

Numero CAS:
Numero CE:
Numero MDL:
Codice UNSPSC:
23151817
NACRES:
NA.56

Forma fisica

powder

Livello qualitativo

tecniche

activity assay: suitable

Matrice

polystyrene/divinylbenzene

pH

4—6

Capacità

~1.0 meq/g(dry)

Applicazioni

Cholestyramine resin has been used:
  • as a diet supplement to study the bile acid pool size and fecal bile acid output in mice
  • to alter the bile acid (BA) levels and study its effect on liver fibrosis development in wild type (WT), fibroblast growth factor 15 (Fgf15)−/−, and Fgf15 transgenic (TG) mice
  • in in vitro digestion process to study the capacity of the fractions for binding bile acid (BA)

Cholestyramine resin is used in protein chromatography, ion exchange chromatography and anion exchange media. Cholestyramine has been used to study the relief of postcholecystectomy diarrhea, the management of intractable cholestatic pruritus and obesity.

Azioni biochim/fisiol

Cholestyramine is a cationic exchange resin polymer. This resin is a bile acid sequestrant that interchanges chloride anions for bile acids of the small intestine lumen, leading to excretion of bile acids in the feces and reduced levels of serum bile acid. Cholestyramine is used to treat primary hypercholesterolemia. The resin induces dose-dependent reduction of low-density lipid (LDL) cholesterol. It ameliorates the risk of coronary artery disease.

Altre note

Quartenary ammonium functional groups attached to cross-linked polystyrene

Note legali

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


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