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Key Documents

C1399

Sigma-Aldrich

Monoclonal Anti-Cytokeratin Peptide 18 antibody produced in mouse

clone KS-B17.2, ascites fluid

Sinonimo/i:

Anti-CK18

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About This Item

Numero MDL:
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

mouse

Coniugato

unconjugated

Forma dell’anticorpo

ascites fluid

Tipo di anticorpo

primary antibodies

Clone

KS-B17.2, monoclonal

contiene

15 mM sodium azide

Reattività contro le specie

human

tecniche

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect immunofluorescence: 1:100 using formalin-fixed, paraffin-embedded sections of human tissue
microarray: suitable

Isotipo

IgG1

N° accesso UniProt

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... KRT18(3875)

Descrizione generale

Monoclonal anti-Cytokeratin Peptide 18 (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.

Specificità

The antibody reacts with a wide variety of simple epithelia (gastrointestinal, respiratory, urinary, liver, and glandular) but does not react with most stratified squamous epithelium (esophagus, epidermis) or non-epithelial cells.

Immunogeno

keratin from the bovine mammary gland epithelial cell line BMGE.

Applicazioni

Monoclonal Anti-Cytokeratin Peptide 18 antibody produced in mouse has been used in:
  • immunofluorescence
  • immunoperoxidase staining
  • immunocytochemistry
  • microarray

Azioni biochim/fisiol

Cytokeratins are proteins of keratin-containing intermediate filaments that provide mechanical support and other additional functions in epithelial cells. It is found in the intracytoplasmic cytoskeleton of epithelial tissue. Epithelial tissue expresses cytokeratin subunits in a specific and stable pattern. Cytokeratins along with vimentin are involved in cell proliferation, migration and differentiation of preodontoblasts and preameloblasts. The intermediate-sized filaments are abundant in human endothelial cells and are mostly of vimentin type.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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B Lifschitz-Mercer et al.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 8(4), 349-356 (1989-01-01)
Cytoskeletal typing of five chorangiomas revealed diffuse staining of the blood vessels with antibodies to vimentin and to alpha smooth muscle (alpha-SM) actin, while cytokeratin 18 decorated the blood vessels focally. Focal staining for desmin was observed in two chorangiomas.
The identification and localization of two intermediate filament proteins in the tunic of Styela plicata (Tunicata, Styelidae).
Di Bella MA, et al.
Tissue & cell, 41(6), 381-389 (2009)
J Mühlhauser et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 43(6), 579-589 (1995-06-01)
Cytokeratins (CKs) are related to proliferation and differentiation of epithelial cells. Little knowledge exists about CK patterns in human trophoblast subpopulations (villous and extravillous trophoblasts). To better understand differentiation and function of trophoblast components, we studied the distribution patterns of
B Kaeffer et al.
Cell biology international, 21(5), 303-314 (1997-05-01)
We have studied the effect of sodium orthovanadate, an inhibitor of protein tyrosine phosphatases, on primary cultures of colonocytes and stromal cells. Everted proximal and distal colonic tissue of adult rats were disintegrated by a collagenase/dispase solution for 60 min
P H Chen et al.
Journal of virology, 67(6), 3507-3514 (1993-06-01)
Immunofluorescence studies revealed that adenovirus induces a reorganization of the cytokeratin system in lytically infected HeLa cells. At 24 h postinfection, the cytokeratin network began to disassemble into prominent spheroid globules. By 36 h postinfection, host cell lysis occurred, accompanied

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