B1686

BIO

≥98% (HPLC), powder, GSK-3α/β inhibitor

• Sinonimo/i: (2’Z,3’E)-6-Bromoindirubin-3′-oxime, 6-BIO, 6BIO
• Formula empirica (notazione di Hill): C₁₆H₁₀BrN₃O₂
• Numero CAS: 667463-62-9
• Peso molecolare: 356.17
• Numero MDL: MFCD08705318
• Codice UNSPSC: 12352200
• ID PubChem: 24724412
• NACRES: NA.77

Proprietà

• Nome del prodotto: BIO, ≥98% (HPLC)
• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Condizioni di stoccaggio: protect from light
• Colore: dark red
• Solubilità: DMSO: >5 mg/mL
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O\N=C1\C(Nc2ccccc12)=C3\C(=O)Nc4cc(Br)ccc34
• InChI: 1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18,22H,(H,19,21)/b15-13-,20-14+; DDLZLOKCJHBUHD-WAVHTBQISA-N

Descrizione

Applicazioni

6-bromoindirubin-3′-oxime (BIO) has been used:

• in MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) cell proliferation assay
• as a medium supplement in embryonic stem cells (ESCs)
• for the inhibition of glycogen synthase kinase 3 β (GSK-3β) in human dermal papilla cells (hDPCs)

Azioni biochim/fisiol

6-bromoindirubin-3′-oxime (BIO) is a potent, reversible and ATP-competitive GSK-3α/β inhibitor and the first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells. Human embryonic stem cells (hESCs) are maintained in the undifferentiated state through treatment with a GSK-3 inhibitor, BIO, under a feeder-free condition.

Caratteristiche e vantaggi

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Confezionamento

air sensitive

Note legali

Product is sold for research and laboratory purposes in vitro and may not be used for any in vivo or therapeutic uses in humans, veterinary applications, or to make chemical derivatives.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves