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Merck
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Key Documents

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B154

Sigma-Aldrich

BU224 hydrochloride

solid

Sinonimo/i:

2-(4,5-Dihydroimidazol-2-yl)quinoline hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C12H11N3 · HCl
Peso molecolare:
233.70
Numero MDL:
MFCD00467639
Codice UNSPSC:
12352202
ID PubChem:
24277761
NACRES:
NA.77

Forma fisica

solid

Colore

white

Solubilità

ethanol: 1.2 mg/mL
H2O: >16 mg/mL
0.1 M NaOH: 24 mg/mL
0.1 M HCl: >30 mg/mL

Stringa SMILE

Cl[H].C1CN=C(N1)c2ccc3ccccc3n2

InChI

1S/C12H11N3.ClH/c1-2-4-10-9(3-1)5-6-11(15-10)12-13-7-8-14-12;/h1-6H,7-8H2,(H,13,14);1H
DDFHQXAQWZWRSQ-UHFFFAOYSA-N

Azioni biochim/fisiol

I2 Imidazoline receptor antagonist.

Caratteristiche e vantaggi

This compound is featured on the Imidazoline Binding Sites page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Avvertenza

Hygroscopic; store desiccated

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319,H335

Consigli di prudenza

P261 - P305 + P351 + P338

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Kazunori Kawamura et al.
Nuclear medicine and biology, 45, 1-7 (2016-11-12)
A positron emission tomography (PET) probe with ultra-high specific radioactivity (SA) enables measuring high receptor specific binding in brain regions by avoiding mass effect of the PET probe itself. It has been reported that PET probe with ultra-high SA can
A L Hudson et al.
Annals of the New York Academy of Sciences, 881, 81-91 (1999-07-23)
Over several years our group has sought to synthesize and identify selective ligands for imidazoline (I) receptors, in particular the I2 binding site. As a consequence, [3H]2-(2-benzofuranyl)-2-imidazoline (2BFI) has proved extremely useful for binding and autoradiographic studies. More recently we
A Diaz et al.
European journal of pharmacology, 333(1), 9-15 (1997-08-20)
In this electrophysiological study, the effect of BU-224 (2-(4,5-dihydroimidazol-2yl)-quinoline hydrochloride)), a novel high affinity imidazoline I2 receptor ligand, was tested on the responses of nociceptive neurones in the spinal dorsal horn. When applied spinally, akin to an intrathecal application (i.t.)
Laura Micheli et al.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 17(3), 1005-1015 (2020-06-24)
Anti-cancer therapy based on the repeated administration of oxaliplatin is limited by the development of a disabling neuropathic syndrome with detrimental effects on the patient's quality of life. The lack of effective pharmacological approaches calls for the identification of innovative
Eloísa Rubio-Beltrán et al.
European journal of pharmacology, 812, 97-103 (2017-07-12)
Calcitonin gene-related peptide (CGRP) plays a role in several (patho)physiological functions, and modulation of its release is considered a therapeutic target. In this respect, electrical spinal (T
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