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88640

Sigma-Aldrich

1-tioglicerolo

≥99.0% (GC)

Sinonimo/i:

αα-monotioglicerolo, αα-tioglicerolo, 3-mercapto-1,2-propanediolo

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About This Item

Formula condensata:
HSCH2CH(OH)CH2OH
Numero CAS:
96-27-5
Peso molecolare:
108.16
Beilstein:
1732046
Numero CE:
202-495-0
Numero MDL:
MFCD00004879
Codice UNSPSC:
12352211
ID PubChem:
57653274
NACRES:
NA.25

Livello qualitativo

200

Saggio

≥99.0% (GC)

Forma fisica

liquid

Indice di rifrazione

n20/D 1.527 (lit.)
n20/D 1.528

P. eboll.

118 °C/5 mmHg (lit.)

Densità

1.25 g/mL at 25 °C (lit.)

Stringa SMILE

OCC(O)CS

InChI

1S/C3H8O2S/c4-1-3(5)2-6/h3-6H,1-2H2
PJUIMOJAAPLTRJ-UHFFFAOYSA-N

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Applicazioni

1-Thioglycerol, a derivatization reagent, is used to study the pH-sensitive photoluminescence of aqueous thiol-capped CdTe nanocrystals. 1-Thioglycerol is used to develop and test thiol-functionalized copolymers. 1-Thioglycerol is used as a post-modification agent in the generation of non-standard peptide foldamers.Potential substitute for 2-mercaptoethanol; probe for the study of lymphocyte activation.

Nota sulla preparazione

This product is miscible in ethanol (1 ml/ml, 50%, v/v), yielding a clear, colorless solution. It is also miscible in water (0.1 M).

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H302,H311 + H331,H315,H317

Classi di pericolo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Skin Irrit. 2 - Skin Sens. 1B

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

210.2 °F - closed cup

Punto d’infiammabilità (°C)

99 °C - closed cup

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Ethyl oleate technical grade, 70%

Sigma-Aldrich

317675

Ethyl oleate

Ethyl oleate tested according to Ph. Eur.

Sigma-Aldrich

75100

Ethyl oleate

N-Acetyl-L-cysteine methyl ester ≥90% (HPLC)

Sigma-Aldrich

01042

N-Acetyl-L-cysteine methyl ester

Doramectin VETRANAL®, analytical standard

Supelco

33993

Doramectin

Chlorobutanol Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1545

Chlorobutanol

Poli(etilenglicole) tested according to Ph. Eur., 6,000

Sigma-Aldrich

03394

Poli(etilenglicole)

M G Goodman et al.
The Journal of experimental medicine, 145(3), 473-489 (1977-03-01)
The effect of 2-mercaptoethanol (2-ME) and alpha-thioglycerol (alpha TG) on proliferation and polyclonal activation of lymphocytes was studied in cultures of spleen cells from C3H mice. Inclusion in serum-free or serum-containing medium of the optimal concentration (5 x 10(-5) M)
Kimiko Ishiguro et al.
Molecular cancer therapeutics, 4(11), 1755-1763 (2005-11-09)
Cloretazine (VNP40101M; 101M; 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine) is a sulfonylhydrazine prodrug that generates both chloroethylating and carbamoylating species on activation. To explore the molecular mechanisms underlying the broad anticancer activity observed in preclinical studies, cloretazine and chloroethylating-only [i.e., 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine] and carbamoylating-only (i.e., 1,2-bis(methylsulfonyl)-1-[(methylamino)carbonyl]hydrazine)
P Tengvall et al.
Biomaterials, 17(10), 1001-1007 (1996-05-01)
Thiol-modified surfaces are chemically well defined and suited for surface biological model experiments and biomaterials research. 3-Mercapto-1,2-propanediol (mercaptoglycerol, MG), immobilized on gold, spontaneously binds immunoglobulins from human serum and activates the complement system. The surface-bound complement factors were detected by
Jonas Wetterö et al.
Biomaterials, 23(4), 981-991 (2002-01-17)
Since the realization of a complement activation capacity by artificial surfaces upon contact with blood, a common belief has evolved that charged nucleophilic surface groups such as amine (-NH2) and hydroxyl (-OH) react with and eventually bind to the internal
Valérie Gagnard et al.
Bioorganic & medicinal chemistry, 12(6), 1393-1402 (2004-03-17)
A new enzyme-labile group called S-acyl-3-thiopropyl group (SATP) has been synthesized from allylic esters of phosphonate. After demonstration of the enzyme-labile character of the SATP in cellular extracts, it has been introduced onto the phosphonate moiety of PFA (Foscarnet) to
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