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Documenti fondamentali

330M-1

Sigma-Aldrich

S-100 (4C4.9) Mouse Monoclonal Antibody

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

100
500

Coniugato

unconjugated

Forma dell’anticorpo

diluted ascites fluid

Tipo di anticorpo

primary antibodies

Clone

4C4.9, monoclonal

Descrizione

For In Vitro Diagnostic Use in Select Regions (See Chart)

Stato

buffered aqueous solution

Reattività contro le specie

human

Confezionamento

vial of 0.1 mL concentrate (330M-14)
vial of 0.5 mL concentrate (330M-15)
bottle of 1.0 mL predilute (330M-17)
vial of 1.0 mL concentrate (330M-16)
bottle of 7.0 mL predilute (330M-18)

Produttore/marchio commerciale

Cell Marque®

tecniche

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200

Isotipo

IgG2a

Controllo

melanoma

Condizioni di spedizione

wet ice

Temperatura di conservazione

2-8°C

Visualizzazione

cytoplasmic, nuclear

Informazioni sul gene

human ... S100A1(6271)

Categorie correlate

Descrizione generale

S-100 protein has been found in normal melanocytes, Langerhans cells, histiocytes, chondrocytes, lipocytes, skeletal and cardiac muscle, Schwann cells, epithelial and myoepithelial cells of the breast, salivary and sweat glands, as well as in glial cells.Neoplasms derived from these cells also express S-100 protein, albeit non-uniformly. A large number of well differentiated tumors of the salivary gland, adipose and cartilaginous tissue, and Schwann cell-derived tumors express S-100 protein. Almost all malignant melanomas and cases of histiocytosis X are positive for S-100 protein. Despite the fact that S-100 protein is an ubiquitous substance, its demonstration is of great value in the identification of several neoplasms, particularly melanomas.

Qualità


IVD
IVD
IVD
RUO

Linkage

S-100 Positive Control Slides, Product No. 330S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Stato fisico

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota sulla preparazione

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Altre note

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Note legali

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
0000299350
0000299351
0000299351
0000299350
1425201A-Z

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T Nakajima et al.
The American journal of surgical pathology, 6(8), 715-727 (1982-12-01)
The presence of S-100 protein was immunohistochemically studied in many types of formalin-fixed and paraffin-embedded tumors (260 cases). Peripheral nerve tumors, i.e., schwannomas, neurofibromas, granular cell tumors, and neurogenic sarcomas were demonstrated to contain variable amounts of S-100 protein in
H J Kahn et al.
American journal of clinical pathology, 79(3), 341-347 (1983-03-01)
Normal tissues and various tumors were examined for S100 protein, using anti-S100 protein antiserum, in an immunoperoxidase reaction. Among normal tissues, in addition to the previously reported presence of S100 protein in some neurons, glial, and Schwann cells of the
K M McLaren et al.
Human pathology, 27(7), 633-636 (1996-07-01)
In general, the diagnosis of papillary carcinoma of the thyroid is readily achieved based on a defined aggregate of histopathologic features. A papillary architecture is an important but not pivotal component of the diagnosis. The recognition of classic nuclear features
Purvisha Patel et al.
Journal of the American Academy of Dermatology, 46(2), 264-270 (2002-01-25)
Malignant myxoid melanoma (MMM) is a rarely reported variant of malignant melanoma, which can often be confused with other mucin-containing neoplasms. A retrospective study of 3 cases of MMM and a review of the English-language literature was performed. MMM affects
L Monda et al.
Human pathology, 16(3), 287-293 (1985-03-01)
In an effort to investigate the utility of immunostaining for S-100 protein in the differential diagnosis of chondroblastoma, the expression of S-100 protein in nine chondroblastomas was compared with that in six giant cell tumors, six aneurysmal bone cysts, four
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Articoli

Immunohistochemistry: Current Applications in Skin Cancer

Immunohistochemistry (IHC) techniques and applications have greatly improved, dermatopathology is still largely based on H&E stained slides.This paper outlines ways in which IHC antibodies can be utilized for dermatopathology.

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