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S0883

Sigma-Aldrich

Sulfasalazine

97.0-101.5%

Sinonimo/i:

2-Hydroxy-5-{{4-[(2-pyridinylamino)sulfonyl]phenyl}azo}benzoic acid, 5-[4-(2-Pyridylsulfamoyl)phenylazo]salicylic acid, Salicylazosulfapyridine

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About This Item

Formula empirica (notazione di Hill):
C18H14N4O5S
Numero CAS:
599-79-1
Peso molecolare:
398.39
Beilstein:
356241
Numero CE:
209-974-3
Numero MDL:
MFCD00057363
Codice UNSPSC:
41116107
ID PubChem:
329824182
NACRES:
NA.24

Livello qualitativo

200

Saggio

97.0-101.5%

Forma fisica

powder

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Punto di fusione

260-265 °C (dec.) (lit.)

applicazioni

forensics and toxicology
pharmaceutical (small molecule)

Modalità d’azione

DNA synthesis | interferes
enzyme | inhibits

Stringa SMILE

OC(=O)c1cc(ccc1O)\N=N\c2ccc(cc2)S(=O)(=O)Nc3ccccn3

InChI

1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+
NCEXYHBECQHGNR-QZQOTICOSA-N

Informazioni sul gene

human ... ALOX5(240) , PTGS1(5742) , PTGS2(5743)

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Categorie correlate

Descrizione generale

Chemical structure: sulfonamide
Sulfasalazine (SSZ) belongs to the sulfonamide class of drugs, which can be metabolized into 5-aminosalicylic acid and sulfapyridine. SSZ is obtained as a reaction product of an antibacterial agent (sulfapyridine) and an anti-inflammatory agent (salicylic acid).

Applicazioni

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Sulfasalazine has been used as an analytical standard in clinical studies:
  • For investigating its therapeutic potential in patients suffering from multiple sclerosis (MS).
  • For studying its role as an antiarthritic agent via inhibition of the cartilage degeneration and pain associated with progression of osteoarthritis in the rat, which is used as the test animal.

It may also be used as an analytical reference standard for the quantification of the analyte in biological samples and aqueous samples using enzyme-linked immunosorbent assay (ELISA) and spectrofluorimetic technique.



Pittogrammi

Health hazardEnvironment
GHS08,GHS09

Avvertenze

Danger

Indicazioni di pericolo

H317,H334,H351,H361f,H411

Classi di pericolo

Aquatic Chronic 2 - Carc. 2 - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
029M4794V
019M4892V
019M4773V
078M4898V
048M4826V

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