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RDD039

Sigma-Aldrich

Imidazolo

for molecular biology, ≥99% (titration), free-flowing, Redi-Dri™

Sinonimo/i:

1,3-diaza-2,4-ciclopentadiene, Gliossalina

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About This Item

Formula empirica (notazione di Hill):
C3H4N2
Numero CAS:
288-32-4
Peso molecolare:
68.08
Beilstein:
103853
Numero MDL:
MFCD00005183
Codice UNSPSC:
12352200
NACRES:
NA.21

Grado

for molecular biology

Livello qualitativo

100

Tensione di vapore

<1 mmHg ( 20 °C)

Nome Commerciale

Redi-Dri™

Saggio

≥99% (titration)

Stato

crystalline powder

Qualità

free-flowing

pH

6.2-7.8 (25 °C)

pKa (25 °C)

6.95

P. ebollizione

256 °C (lit.)

Punto di fusione

88-91 °C (lit.)

applicazioni

diagnostic assay manufacturing

Attività estranea

DNase, RNase and protease, none detected

Stringa SMILE

c1c[nH]cn1

InChI

1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)
RAXXELZNTBOGNW-UHFFFAOYSA-N

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Descrizione generale

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar.

Applicazioni

Ottimo per tamponi nell′intervallo di pH 6,2-7,8
Imidazole has been used
  • in the lysis, wash, and elution buffer for the purification of histidine tagged proteins
  • in gradient for the purification of histidine tagged proteins using nickel affinity chromatography
  • as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells

Azioni biochim/fisiol

Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).

Caratteristiche e vantaggi

  • Qualified for molecular biology applications, DNase, Rnase, and protease free
  • Redi-Dri™ packaging controls moisture, eliminating clumps
  • Crystalline powder remains free-flowing and much easier to use
  • Safer to handle and weigh out for routine use in lab
  • Less waste, loss of drying, while maintaining high quality

Altre note

For additional information on our range of Biochemicals, please complete this form.

Note legali

Redi-Dri is a trademark of Sigma-Aldrich Co. LLC

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Avvertenze

Danger

Indicazioni di pericolo

H302,H314,H360D

Classi di pericolo

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1B - Skin Corr. 1C

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

293.0 °F - closed cup

Punto d’infiammabilità (°C)

145 °C - closed cup

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Certificati d'analisi (COA)

Lot/Batch Number
SLCG7433

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Molecular pathways regulating pro-migratory effects of Hedgehog signaling
Hochman E, et al.
The Journal of Biological Chemistry, 281(45), 33860-33870 (2006)
Bernd Zetsche et al.
Cell, 163(3), 759-771 (2015-10-01)
The microbial adaptive immune system CRISPR mediates defense against foreign genetic elements through two classes of RNA-guided nuclease effectors. Class 1 effectors utilize multi-protein complexes, whereas class 2 effectors rely on single-component effector proteins such as the well-characterized Cas9. Here
Alan M Sandercock et al.
Molecular cancer, 14, 147-147 (2015-08-01)
Monolayer cultures of immortalised cell lines are a popular screening tool for novel anti-cancer therapeutics, but these methods can be a poor surrogate for disease states, and there is a need for drug screening platforms which are more predictive of
Pam M Van Ry et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 23(8), 1285-1297 (2015-06-09)
Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disease caused by mutations in the dystrophin gene, leading to the loss of a critical component of the sarcolemmal dystrophin glycoprotein complex. Galectin-1 is a small 14 kDa protein normally found in skeletal
Ali Tebbi et al.
The Journal of biological chemistry, 290(22), 14077-14090 (2015-04-17)
Ribonucleotide reductase (RnR) is a key enzyme synthesizing deoxyribonucleotides for DNA replication and repair. In mammals, the R1 catalytic subunit forms an active complex with either one of the two small subunits R2 and p53R2. Expression of R2 is S
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Redi-Dri™ – The World of Free-flowing Hygroscopic Products

Redi-Dri™ prevents hygroscopic powders, such as inorganic salts, from absorbing moisture and forming clumps, leaving the salts free-flowing every time.

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