PHR1932

Isoniazide

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinonimo/i: 4-Pyridinecarboxylic acid hydrazide, INH, Idrazide isonicotinica, idrazide dell’acido isonicotinico
• Formula empirica (notazione di Hill): C₆H₇N₃O
• Numero CAS: 54-85-3
• Peso molecolare: 137.14
• Beilstein: 119374
• Numero CE: 200-214-6
• Numero MDL: MFCD00006426
• Codice UNSPSC: 41116107
• NACRES: NA.24

Proprietà

• Grado: certified reference material; pharmaceutical secondary standard
• Livello qualitativo: 300
• agenzia: traceable to BP 1083; traceable to Ph. Eur. I0500000; traceable to USP 1349706
• Famiglia di API: isoniazid
• Forma fisica: powder
• CdA: current certificate can be downloaded
• Confezionamento: pkg of 500 mg
• Punto di fusione: 171-173 °C (lit.)
• applicazioni: pharmaceutical
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: NNC(=O)c1ccncc1
• InChI: 1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10); QRXWMOHMRWLFEY-UHFFFAOYSA-N

Descrizione

Descrizione generale

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Applicazioni

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Azioni biochim/fisiol

Antibiotico per il trattamento del Mycobacterium tuberculosis, inibisce la biosintesi dell'acido micolico. Metabolizzato dalla N-acetiltransferasi epatica (NAT) e dal citocromo P450 2E1 (CYP2E1) a formare epatotossine. Induce selettivamente l'espressione del CYP2E1. Inibisce reversibilmente le attività di CYP2C19 e CYP3A4 e inattiva meccanicisticamente CYP1A2, CYP2A6, CYP2C19 e CYP3A4 a concentrazioni clinicamente rilevanti.

Risultati analitici

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Altre note

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota a piè di pagina

To see an example of a Certificate of Analysis for this material enter LRAC3171 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Prodotti consigliati

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H315
• Consigli di prudenza: P264 - P280 - P301 + P312 - P302 + P352 - P332 + P313 - P362 + P364
• Classi di pericolo: Acute Tox. 4 Oral - Skin Irrit. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3