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Key Documents

PHR1687

Supelco

Cicloesano

Pharmaceutical Secondary Standard; Certified Reference Material

Sinonimo/i:

Cyclohexane

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About This Item

Formula empirica (notazione di Hill):
C6H12
Numero CAS:
Peso molecolare:
84.16
Beilstein:
1900225
Numero CE:
Numero MDL:
Codice UNSPSC:
12191502
ID PubChem:
NACRES:
NA.24

Grado

certified reference material
pharmaceutical secondary standard

Livello qualitativo

agenzia

traceable to USP 1601408

Densità del vapore

2.9 (vs air)

Tensione di vapore

168.8 mmHg ( 37.7 °C)
77 mmHg ( 20 °C)

CdA

current certificate can be downloaded

Temp. autoaccensione

500 °F

Limite di esplosione

9 %

Confezionamento

ampule of 3x1.2 mL

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Indice di rifrazione

n20/D 1.426 (lit.)

P. eboll.

80.7 °C (lit.)

Punto di fusione

4-7 °C (lit.)

Densità

0.779 g/mL at 25 °C (lit.)

applicazioni

pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-30°C

Stringa SMILE

C1CCCCC1

InChI

1S/C6H12/c1-2-4-6-5-3-1/h1-6H2
XDTMQSROBMDMFD-UHFFFAOYSA-N

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Descrizione generale

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Cyclohexane is a nonpolar, flammable liquid that belongs to the group of cycloalkanes. In general, cyclohexane is obtained by hydrogenation of benzene and predominately used in the nylon industry. It also finds application in pharmaceutical applications.

Applicazioni

Cyclohexane can be used as a pharmaceutical reference standard for residual solvent analysis in pharmaceutical formulations and raw materials by gas chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Risultati analitici

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Altre note

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota a piè di pagina

To see an example of a Certificate of Analysis for this material enter LRAC0291 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Prodotti consigliati

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Avvertenze

Danger

Indicazioni di pericolo

Classi di pericolo

Aquatic Acute 1 - Aquatic Chronic 1 - Asp. Tox. 1 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Central nervous system

Codice della classe di stoccaggio

3 - Flammable liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

-4.0 °F - closed cup

Punto d’infiammabilità (°C)

-20 °C - closed cup


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Certificati d'analisi (COA)

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Residual solvents determination in drug products by static headspace-gas chromatography
Camarasu CC
Chromatographia, 56(1), S137-S143 (2002)
Pervaporation: Membrane Separations
Encyclopedia of Separation Science, 3636-3641 (2000)
Validation of a generic analytical procedure for determination of residual solvents in drug substances
Klick S and Skold A
Journal of Pharmaceutical and Biomedical Analysis, 36(2), 401-409 (2004)
Organic solvents in the pharmaceutical industry
Grodowska K and Parczewski A
Acta Poloniae Pharmaceutica, 67(1), 3-12 (2010)

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