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Key Documents

Altri documenti

PHR1319

Supelco

Residual Solvent - Trichloroethylene

Pharmaceutical Secondary Standard; Certified Reference Material

Sinonimo/i:

Trichloroethylene, TCE, Trichloroethene

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About This Item

Formula condensata:
ClCH=CCl2
Numero CAS:
79-01-6
Peso molecolare:
131.39
Beilstein:
1736782
Numero MDL:
MFCD00000838
Codice UNSPSC:
41116107
ID PubChem:
329823304

Grado

certified reference material
pharmaceutical secondary standard

Livello qualitativo

300

agenzia

traceable to USP 1601827

Densità del vapore

4.5 (vs air)

Tensione di vapore

61 mmHg ( 20 °C)

CdA

current certificate can be downloaded

Temp. autoaccensione

770 °F

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Indice di rifrazione

n20/D 1.476 (lit.)

P. eboll.

86.7 °C (lit.)

Punto di fusione

−84.8 °C (lit.)

Densità

1.463 g/mL at 25 °C (lit.)

applicazioni

pharmaceutical (small molecule)

Formato

single component solution

Temperatura di conservazione

2-30°C

Stringa SMILE

Cl\C=C(\Cl)Cl

InChI

1S/C2HCl3/c3-1-2(4)5/h1H
XSTXAVWGXDQKEL-UHFFFAOYSA-N

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Descrizione generale

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Residual Solvent - Trichloroethylene belongs to the group of class 2 residual solvents. The use of class 2 solvents should be limited in drug substances, excipients, dietary ingredients, and official products because of the inherent toxicities of these residual solvents. Trichloroethylene is a volatile and chlorinated organic compound, which finds applications as a solvent and greasing agent.

Applicazioni

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Altre note

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota a piè di pagina

To see an example of a Certificate of Analysis for this material enter LRAA0678 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pittogrammi

Health hazard
GHS08

Avvertenze

Danger

Indicazioni di pericolo

H350

Classi di pericolo

Carc. 1B

Codice della classe di stoccaggio

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

188.6 °F - closed cup

Punto d’infiammabilità (°C)

87 °C - closed cup

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Certificati d'analisi (COA)

Lot/Batch Number
LRAC8766
LRAB2955
LRAA0678

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Residual Solvents Mixture - Class IIB Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1065

Residual Solvents Mixture - Class IIB

Yih-Horng Shiao
Environmental and molecular mutagenesis, 50(1), 68-77 (2008-11-26)
Trichloroethylene (TCE), an organic solvent commonly used for metal degreasing and as a chemical additive, is a significant environmental contaminant that poses health concerns in humans. The US Environmental Protection Agency (EPA) is currently revising the 2001 TCE human risk
Jane C Caldwell et al.
Environmental and molecular mutagenesis, 49(2), 142-154 (2007-11-02)
The mode(s) of action (MOA) of a pollutant for adverse health effects may be dependent on the mixture of metabolites resulting from exposure to a single agent and may also be affected by coexposure to pollutants that have similar targets
Cheryl Siegel Scott et al.
International journal of environmental research and public health, 8(11), 4238-4272 (2011-12-14)
We conducted a meta-analysis focusing on studies with high potential for trichloroethylene (TCE) exposure to provide quantitative evaluations of the evidence for associations between TCE exposure and kidney, liver, and non-Hodgkin lymphoma (NHL) cancers. A systematic review documenting essential design
Jane C Caldwell et al.
Environmental health perspectives, 114(9), 1457-1463 (2006-09-13)
Trichloroethylene (TCE) exposure has been associated with increased risk of liver and kidney cancer in both laboratory animal and epidemiologic studies. The U.S. Environmental Protection Agency 2001 draft TCE risk assessment concluded that it is difficult to determine which TCE
Berit Bakke et al.
Journal of occupational and environmental hygiene, 4(5), 375-390 (2007-04-25)
This article describes a systematic review of the industrial hygiene literature for uses of trichloroethylene (TCE) in industry for the exposure assessment of two population-based case control studies of brain cancer in the United States. Papers and reports that address
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