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P5654

Sigma-Aldrich

Piroxicam

≥98% (TLC)

Sinonimo/i:

4-Hydroxy-2-methyl-3-(pyrid-2-yl-carbamoyl)-2H-1,2-benzothiazine 1,1-dioxide

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About This Item

Formula empirica (notazione di Hill):
C15H13N3O4S
Numero CAS:
36322-90-4
Peso molecolare:
331.35
Numero CE:
252-974-3
Numero MDL:
MFCD00057317
Codice UNSPSC:
41116107
ID PubChem:
24278641
NACRES:
NA.77

Origine biologica

synthetic (organic)

Livello qualitativo

100

Saggio

≥98% (TLC)

Stato

powder

Temperatura di conservazione

2-8°C

Stringa SMILE

CN1C(C(=O)Nc2ccccn2)=C(O)c3ccccc3S1(=O)=O

InChI

1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20)
QYSPLQLAKJAUJT-UHFFFAOYSA-N

Informazioni sul gene

human ... PTGS1(5742) , PTGS2(5743)
rat ... Alox5(25290)

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Applicazioni

Piroxicam has been used:
  • for the induction of colitis in mice
  • as a non-steroidal anti-inflammatory drug to increase the sensitivity to gut injury in interleukin-10 (IL-10) knockout mice
  • as a chemopreventive agent and as a positive control to study its effects on tumor growth in mice small intestine

Azioni biochim/fisiol

Cyclooxygenase inhibitor.
Piroxicam is a non‐steroidal anti‐inflammatory drug (NSAID). It possesses analgesic properties and exhibits therapeutic effects against rheumatic disorders.

Pittogrammi

Skull and crossbonesHealth hazard
GHS06,GHS08

Avvertenze

Danger

Indicazioni di pericolo

H301,H373

Classi di pericolo

Acute Tox. 3 Oral - STOT RE 2 Oral

Organi bersaglio

Gastrointestinal tract

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
SLCK4830
SLCH0606
SLCD8266
SLBZ7472
SLBX7230

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Clonixin ≥98% (HPLC)

Sigma-Aldrich

SML0530

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Supelco

PHR1288

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Lornoxicam ≥98% (HPLC)

Sigma-Aldrich

SML0338

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vibrant-m

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Sigma-Aldrich

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Etodolac

Sigma-Aldrich

E0516

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Sulindac ≥98.0%

Sigma-Aldrich

S8139

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Diflunisal analytical standard

Supelco

D3281

Diflunisal

Thymoquinone attenuates tumor growth in ApcMin mice by interference with Wnt-signaling
Lang M, et al.
Molecular Cancer, 12(1), 41-41 (2013)
Jiawei Guo et al.
Cell reports. Medicine, 4(1), 100881-100881 (2023-01-06)
Systematic bone loss is commonly complicated with inflammatory bowel diseases (IBDs) with unclear pathogenesis and uncertain treatment. In experimental colitis mouse models established by dextran sulfate sodium and IL-10 knockout induced with piroxicam, bone mass and quality are significantly decreased.
T J Carty et al.
Prostaglandins, 19(1), 51-59 (1980-01-01)
The new non-steroidal antiinflammatory (NSAI)2 agent, piroxicam [4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide], is a highly active inhibitor of prostaglandin (PG) synthesis by methylcholanthrene transformed mouse fibroblasts (MC5-5) and rabbit synovial cells in culture. Comparison of the PG biosynthesis inhibitory activity of piroxicam with
Seung-Won Choi et al.
Plant biotechnology (Tokyo, Japan), 39(3), 323-327 (2022-11-10)
Agrobacterium-mediated transformation is a key innovation for plant breeding, and routinely used in basic researches and applied biology. However, the transformation efficiency is often the limiting factor of this technique. In this study, we discovered that oxicam-type nonsteroidal anti-inflammatory drugs
Wanwadee Luksurapan et al.
Archives of physical medicine and rehabilitation, 94(2), 250-255 (2012-10-16)
To compare the effects of phonophoresis of piroxicam (PhP) and ultrasound therapy (UT) in patients with mild to moderate, symptomatic knee osteoarthritis (OA). A randomized, double-blind, controlled trial. Department of rehabilitation medicine, university hospital. Patients with knee OA (N=46; mean
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