61076

DL-4-Hydroxy-2-ketoglutaric acid lithium salt

analytical standard

• Sinonimo/i: 4-Hydroxy-2-oxoglutaric acid lithium salt, DL-KHG Li
• Formula empirica (notazione di Hill): C₅H₆O₆ · xLi⁺
• Numero CAS: 1187-99-1
• Peso molecolare: 162.10 (free acid basis)
• Beilstein: 1780096
• Codice UNSPSC: 41116107

Proprietà

• Grado: analytical standard
• Saggio: ≥97.0% (HPLC)
• Durata: limited shelf life, expiry date on the label
• applicazioni: clinical testing
• Formato: neat
• Temperatura di conservazione: −20°C
• InChI: 1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11); WXSKVKPSMAHCSG-UHFFFAOYSA-N

Descrizione

Descrizione generale

DL-4-Hydroxy-2-ketoglutaric acid lithium salt (HOG) is a precursor substrate of 4-hydroxy-2-oxoglutarate aldolase (HOGA1), a unique enzyme in the hydroxyproline catabolism pathway. It is reported that the primary hyperoxaluria type 3, which is a recently discovered form of the autosomal recessive disease, results from the mutations in the gene coding for HOGA1.

Applicazioni

DL-4-Hydroxy-2-ketoglutaric acid lithium salt may be used as an analytical reference standard for the determination of the analyte in animal biological samples using ion chromatography coupled to negative electrospray mass spectrometry (IC/ES-MS). This can be used to determine the primary hyperoxalurias PH Type 3 (PH3), caused by the mutations in the mitochondrial enzyme, 4-hydroxy-2-oxoglutarate aldolase (HOGA).

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable