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Key Documents

Altri documenti

47673

Sigma-Aldrich

Formaldeide

tested according to Ph. Eur.

Sinonimo/i:

Formalina

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About This Item

Formula condensata:
HCHO
Numero CAS:
50-00-0
Peso molecolare:
30.03
Beilstein:
1209228
Numero MDL:
MFCD00003274
Codice UNSPSC:
12352114
ID PubChem:
329757334
NACRES:
NA.25

agenzia

USP/NF
tested according to Ph. Eur.

Livello qualitativo

200

Densità del vapore

1.03 (vs air)

Tensione di vapore

52 mmHg ( 37 °C)

Forma fisica

liquid

Temp. autoaccensione

572 °F

contiene

9.0-15.0 % (v/v) methanol as stabilizer

Concentrazione

25-50%

Solubilità

water: soluble

Densità

1.09 g/mL at 25 °C (lit.)

Compatibilità

suitable for manufacturing use (Laboratory chemicals)

Stringa SMILE

[H]C([H])=O

InChI

1S/CH2O/c1-2/h1H2
WSFSSNUMVMOOMR-UHFFFAOYSA-N

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Applicazioni

Formaldehyde solution has been used to fix labeled cells during flow cytometry.

Azioni biochim/fisiol

Formaldehyde is the simplest aldehyde that denatures the bihelical regions of RNA and converts the polynucleotides into random coils. It is a genotoxic substance that significantly induces DNA-protein crosslinks (DPC), sister-chromatid exchanges, micronuclei formation and leads to cytotoxicity. It also induces tumors in the nasal epithelium of rats and supposed to be a human carcinogen.

Avvertenza

may become turbid on storage

Avvertenze

Danger

Classi di pericolo

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Carc. 1B - Eye Dam. 1 - Flam. Liq. 3 - Muta. 2 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 1 - STOT SE 3

Organi bersaglio

Eyes,Central nervous system, Respiratory system

Codice della classe di stoccaggio

3 - Flammable liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

133.0 °F - closed cup

Punto d’infiammabilità (°C)

56.11 °C - closed cup

Dispositivi di protezione individuale

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificati d'analisi (COA)

Lot/Batch Number
BCCJ9557
BCCH9199
BCCG6783
BCCG6784
BCCF6567

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Soluzione di formaldeide al 37% circa GR for analysis stabilized with about 10% methanol ACS,Reag. Ph Eur

Sigma-Aldrich

1.04003

Soluzione di formaldeide al 37% circa

Formaldehyde solution min. 37% free from acid stabilized with about 10% methanol and calcium carbonate for histology

Sigma-Aldrich

1.03999

Formaldehyde solution min. 37% free from acid

Dependence of the sedimentation coefficient on molecular weight of RNA after reaction with formaldehyde.
H Boedtker
Journal of molecular biology, 35(1), 61-70 (1968-07-14)
O Merk et al.
Environmental and molecular mutagenesis, 32(3), 260-268 (1998-11-14)
Formaldehyde (FA) is a genotoxic substance, induces tumors in the nasal epithelium of rats, and is suspected to be a human carcinogen. As a primary DNA lesion, FA induces DNA-protein crosslinks (DPC) and the formation of DPC has been used
J L Wilson et al.
Journal of immunology (Baltimore, Md. : 1950), 163(12), 6365-6370 (1999-12-10)
NK cells have the capacity to spontaneously kill tumor cell lines, in particular cell lines of hemopoietic origin. In contrast, they do not generally kill nontransformed autologous cells. However, here we demonstrate that short-term activated polyclonal human NK cells, as
Cindy S Ma et al.
The Journal of experimental medicine, 205(7), 1551-1557 (2008-07-02)
Hyper-immunoglobulin E syndrome (HIES) is a primary immune deficiency characterized by abnormal and devastating susceptibility to a narrow spectrum of infections, most commonly Staphylococcus aureus and Candida albicans. Recent investigations have identified mutations in STAT3 in the majority of HIES
G R Moore et al.
Neurology, 55(10), 1506-1510 (2000-11-30)
To determine the pathologic basis of areas not exhibiting signal of the short-T2 component of the T2 relaxation distribution in MS, as studied in formalin-fixed brain. A myelin-specific MRI signal would be of great importance in assessing demyelination in patients
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