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RKTX2MAG-37K

Millipore

MILLIPLEX® Rat Kidney Toxicity Magnetic Bead Panel 2 - Toxicity Multiplex Assay

The analytes available for this multiplex kit are: Albumin, AGP, ß2M, Cystatin C, EGF, Lipocalin-2/NGAL.

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About This Item

Codice UNSPSC:
12161503
eCl@ss:
32161000
NACRES:
NA.84

Livello qualitativo

200

Reattività contro le specie

rat

Produttore/marchio commerciale

Milliplex®

assay range

accuracy: 70-123%
standard curve range: 0.00-2 ng/mL
(EGF)
standard curve range: 0.01-10 ng/mL
(Lipocalin-2/NGAL)
standard curve range: 0.01-8 ng/mL
(Cystatin C)
standard curve range: 0.48-350 ng/mL
(β2M)
standard curve range: 1.37-1,000 ng/mL
(AGP)
standard curve range: 10.97-8,000 ng/mL
(Albumin)
inter-assay cv: <15%
intra-assay cv: <10%
(All other analytes)
inter-assay cv: <20%
intra-assay cv: <15%
(AGP)

tecniche

multiplexing: suitable

Metodo di rivelazione

fluorometric (Luminex xMAP)

Condizioni di spedizione

wet ice

Categorie correlate

Descrizione generale

MILLIPLEX® Rat Kidney Toxicity Bead Panels 1 & 2, coupled with the Luminex® xMAP®platform in a bead format, enables you to focus on discovery so you receive the advantage of ideal speed and sensitivity, allowing quantitative multiplex detection of multiple analytes simultaneously, dramatically improving productivity.

Panel Type: Toxicity

Specificità

There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes in this panel.

Applicazioni

  • Analytes: Alpha-1 Acid Glycoprotein (AGP), Albumin, ß2M, Cystatin C, EGF, Lipocalin-2/NGAL
  • Recommended Sample type: urine
  • Recommended Sample dilution: 1:500
  • Assay Run Time: Overnight
  • Research Category: Toxicity

Caratteristiche e vantaggi

Design your multiplex kit by choosing available analytes within this panel.

Confezionamento

Everything you need in a single kit.

Stoccaggio e stabilità

Recommended storage for kit components is 2 - 8°C.

Altre note

Sensitivity: See kit protocol for individual analytes sensitivities.

Note legali

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pittogrammi

Skull and crossbonesEnvironment
GHS06,GHS09

Avvertenze

Danger

Classi di pericolo

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Certificati d'analisi (COA)

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Michael J Coyne et al.
PloS one, 17(5), e0269085-e0269085 (2022-05-28)
Symmetric dimethylarginine (SDMA) is a serum biomarker of excretory renal function which consistently correlates with glomerular filtration rate (GFR) across multiple species including rats, dogs, and humans. In human and veterinary clinical settings SDMA demonstrates enhanced sensitivity for detection of
Kidney biomarkers in MCPA-induced acute kidney injury in rats: reduced clearance enhances early biomarker performance.
Wunnapuk, K; Liu, X; Gobe, GC; Endre, ZH; Peake, PW; Grice, JE; Roberts, MS; Buckley, NA
Toxicology Letters null
Iwan P Williams et al.
mAbs, 12(1), 1685349-1685349 (2019-11-27)
IgE monoclonal antibodies hold great potential for cancer therapy. Preclinical in vivo systems, particularly those in which the antibody recognizes the host species target antigen and binds to cognate Fc receptors, are often the closest approximation to human exposure and
Nadeeka S Udawatte et al.
Frontiers in pharmacology, 11, 511-511 (2020-05-12)
Candida albicans is the major fungal species associated with superficial mucosal infections such as oral candidiasis as well as systemic mycoses with high morbidity and mortality. On top of the rising drug resistance, currently available antifungal agents have significant adverse
Klintean Wunnapuk et al.
Toxicology letters, 225(1), 192-200 (2013-12-24)
Accidental or intentional ingestion of glyphosate surfactant-based herbicides, like Roundup(®), leads to nephrotoxicity as well as death. In this study, a panel of kidney injury biomarkers was evaluated in terms of suitability to detect acute kidney injury and dysfunction. The

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