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HKI1MAG-99K

Millipore

MILLIPLEX® Human Kidney Injury Magnetic Bead Panel 1 - Toxicity Multiplex Assay

The analytes available for this multiplex kit are: Calbindin, Collagen IV, Fatty Acid Binding Protein 1 (FABP1), GSTα, IP-10, Kidney Injury Molecule-1 (KIM-1), Renin, TFF-3, TIMP-1.

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About This Item

Codice UNSPSC:
12161503
eCl@ss:
32161000

Livello qualitativo

200

Reattività contro le specie

human

Produttore/marchio commerciale

Milliplex®

assay range

accuracy: 73-117%
sensitivity: 0.010-6.473 ng/mL
(MinDC = 2SD)
standard curve range: 0.005-5 ng/mL
(IP-10)
standard curve range: 0.02-25 ng/mL
(Renin)
standard curve range: 0.05-50 ng/mL
(GSTα)
standard curve range: 0.05-50 ng/mL
(KIM-1)
standard curve range: 0.10-100 ng/mL
(TIMP-1)
standard curve range: 0.20-200 ng/mL
(Calbindin)
standard curve range: 0.34-350 ng/mL
(Collagen IV)
standard curve range: 0.49-500 ng/mL
(TFF-3)
standard curve range: 5.86-6,000 ng/mL
(FABP1)
inter-assay cv: <15%
intra-assay cv: <10%

tecniche

multiplexing: suitable

Metodo di rivelazione

fluorometric (Luminex xMAP)

Condizioni di spedizione

wet ice

Categorie correlate

Descrizione generale

Maintenance of physiological balance in the body is attributed in part to normal kidney function. Altered kidney function due to injury, drug toxicity or kidney failure may be life threatening. Toxicity is the leading cause of drug failure, so research is expanding in search of more sensitive, rapid methods to determine organ-specific damage as quickly as possible. Traditionally, blood urea nitrogen (BUN) and serum creatinine tests have been used to determine drug-induced damage to the kidney. These tests only detect kidney damage after it begins and do not allow for the elucidation of where in the kidney the damage has occurred. Specificity and earlier detection of kidney injury is vital, and this area of research is expanding in search of more sensitive, rapid methods for determining the specific area of damage in kidney.

The MILLIPLEX® portfolio provides valuable research assays to investigate multiple biomarkers of kidney injury in human urine samples using the Luminex® xMAP® instrument platform. The analytes available for this multiplex kit are: Calbindin, Collagen IV, Fatty Acid Binding Protein 1 (FABP1), GSTα, IP-10, Kidney Injury Molecule-1 (KIM-1), Renin, TFF-3, TIMP-1.

Panel Type: Toxicity

Specificità

Cross Reactivty
There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes within a panel.

Applicazioni

  • Analytes: Calbindin, Collagen IV, FABP1, GSTα, IP-10, KIM-1, Renin, TFF-3, TIMP-1
  • Recommended Sample type: Urine
  • Recommended Sample dilution: 1:2 in kit Assay Buffer Customers need to determine the optimal dilution factor for their samples. Our recommendations are based on urine samples from normal subjects.
  • Assay Run Time: Overnight
  • Research Category: Toxicity

Caratteristiche e vantaggi

Design your multiplex kit by choosing available analytes within this panel.

Altre note

Sensitivity: Please see kit protocol for individual assay sensitivities.

Note legali

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Avvertenze

Danger

Classi di pericolo

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

Organi bersaglio

Respiratory Tract

Codice della classe di stoccaggio

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Certificati d'analisi (COA)

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Irene Capelli et al.
In vivo (Athens, Greece), 34(3), 1333-1339 (2020-05-02)
Acute kidney injury is an important cause of mortality in very-low-birth-weight (VLBW) preterm infants. As in the general population, the detection of renal damage cannot rely on the measurement of serum creatinine, since it has been demonstrated to be a

Contenuto correlato

Nephrotoxicity Analysis with Kidney Toxicity Multiplex Assays | MILLIPLEX® Assays

Novel kidney toxicity biomarkers expand options for acute nephrotoxicity detection. Multiplex assays measure multiple renal damage biomarkers in small sample volumes, minimizing time and costs. See how MILLIPLEX® multiplex kidney toxicity assays detected vancomycin-induced subacute nephrotoxicity in rat models.

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.