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MAGPMAG-24K

Millipore

MILLIPLEX® Mouse Angiogenesis/Growth Factor Magnetic Bead Panel - Cancer Multiplex Assay

for the simultaneous quantification of multiple analytes

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali


About This Item

Codice UNSPSC:
12161503
eCl@ss:
32161000
NACRES:
NA.84

Livello qualitativo

Reattività contro le specie

mouse

Produttore/marchio commerciale

Milliplex®

assay range

accuracy: 90-104%
standard curve range: 1-1,000 pg/mL
(Endothelin-1)

standard curve range: 137-100,000 pg/mL
(Follistatin)

standard curve range: 137-100,000 pg/mL
(HGF)

standard curve range: 137-100,000 pg/mL
(SDF-1)

standard curve range: 14-10,000 pg/mL
(IL-1b)

standard curve range: 14-10,000 pg/mL
(Leptin)

standard curve range: 14-10,000 pg/mL
(MIP-1α)

standard curve range: 14-10,000 pg/mL
(sALK-1)

standard curve range: 14-10,000 pg/mL
(sCD31/ PECAM-1)

standard curve range: 27-20,000 pg/mL
(Angiopoietin-2)

standard curve range: 27-20,000 pg/mL
(EGF)

standard curve range: 27-20,000 pg/mL
(Endoglin)

standard curve range: 27-20,000 pg/mL
(MCP-1)

standard curve range: 27-20,000 pg/mL
(VEGF-C)

standard curve range: 3-2,000 pg/mL
(PLGF-2)

standard curve range: 6-4,000 pg/mL
(TNFα)

standard curve range: 6-4,000 pg/mL
(VEGF-A)

standard curve range: 69-50,000 pg/mL
(FGF-2/FGF-basic)

standard curve range: 69-50,000 pg/mL
(Prolactin)

standard curve range: 69-50,000 pg/mL
(VEGF-D)

standard curve range: 69-50,000 pg/mL
(sFasL)

standard curve range: 7-5,000 pg/mL
(Amphiregulin)

standard curve range: 7-5,000 pg/mL
(Betacellulin)

standard curve range: 7-5,000 pg/mL
(G-CSF)

standard curve range: 7-5,000 pg/mL
(IL-17A)

standard curve range: 7-5,000 pg/mL
(IL-6)

standard curve range: 7-5,000 pg/mL
(KC/CXCL1)

tecniche

multiplexing: suitable

Metodo di rivelazione

fluorometric (Luminex xMAP)

Condizioni di spedizione

wet ice

Descrizione generale

Angiogenesis, the development of new vascular networks, is a key process in normal growth and development as well as in wound healing, with homeostasis maintained by a delicate balance of angiogenic factors and inhibitors. Consequently, insufficient, or excessive blood vessel growth underlies many diseases, including cardiovascular disease, diabetic ulcers, macular degeneration, and cancer. Angiogenesis plays a significant role in tumor growth and metastasis.

MILLIPLEX® Mouse Angiogenesis//Growth Factor Panel, is a 24-plex (for serum/plasma) or 27-plex (for cell culture) kit to be used for the simultaneous quantification of the following analytes: Angiopoietin-2, G-CSF, sFasL, sAlk-1, Amphiregulin, Leptin, IL-1b, Betacellulin, EGF, IL-6, Endoglin, Endothelin-1, FGF-2, Follistatin, HGF, PECAM-1, IL-17, PLGF-2, KC, MCP-1, Prolactin, MIP-1a, SDF-1, VEGF-C, VEGF-D, VEGF-A, and TNFα. This kit uses a 96-well format, contains a lyophilized standard cocktail, two internal assay quality controls and can measure up to 38 samples in duplicate.

The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.

Panel Type: Circulating Cancer

Specificità

Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.

Applicazioni

  • Analytes: sALK-1, Amphiregulin, Angiopoietin-2, Betacellulin, sCD31/sPECAM-1, EGF, Endoglin, Endothelin-1, sFasL, FGF-2 (FGF-basic), Follistatin (FST), G-CSF, HGF, IL-1β, IL-6, IL-17A (CTLA8), KC (GRO/CINC-1/CXCL1), Leptin, MCP-1 (CCL2), MIP-1α (CCL3), Placental Growth Factor 2 (PLGF-2), Prolactin, SDF-1 (CXCL12), TNF-α, VEGF-A, VEGF-C, VEGF-D
  • NOTE: Angiopoeitin-2, Betacellulin, and PECAM-1 should not be run in serum/plasma samples
  • Recommended Sample Type: Mouse serum, plasma or tissue/cell culture supernatants or lysates
  • Recommended Sample Dilution: 25 μL per well of diluted serum or plasma; cell/tissue culture samples may require diltion in appropriate control medium
  • Assay Run Time: Overnight (16-20 hours) at 2-8°C
  • Research Category: Cancer

Caratteristiche e vantaggi

Design your multiplex kit by choosing available analytes within this panel.

Confezionamento

Everything you need in a single kit.

Stoccaggio e stabilità

Recommended storage for kit components is 2 - 8°C.

Altre note

Please note: Sample Type must be selected when configuring this kit. Angiopoeitin-2, Betacellulin, and PECAM-1 should not be run in serum/plasma samples.
Sensitivity: Refer to kit protocol for sensitivities of individual analytes.

Note legali

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Avvertenze

Danger

Classi di pericolo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

Organi bersaglio

Respiratory Tract

Codice della classe di stoccaggio

10 - Combustible liquids


Certificati d'analisi (COA)

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Wenjie Li et al.
Stem cells international, 2022, 8540535-8540535 (2022-06-18)
Adipose-derived stem cells (ASCs) improve the self-renewal and survival of fat grafts in breast reconstruction after oncology surgery. However, ASCs have also been found to enhance breast cancer growth, and its role in tumor proliferation remains largely elusive. Here, we
Pier-Anne Lachance et al.
PloS one, 8(9), e76078-e76078 (2013-10-03)
During acute inflammation, functioning lymphatics are believed to reduce edema and to provide a transiting route for immune cells, but the extent at which the dermal lymphatic remodeling impacts lymphatic transport or the factors regulating these changes remains unclear. Herein
Aziza R Alrafiah
Biomedicines, 9(9) (2021-09-29)
The present study focused on secondary injury following the middle cerebral artery (MCA) occlusion in rats not linked to the MCA's feeding zone. This entity has been very rarely studied. Additionally, this study investigated the rates of expression of five
Sara Luscieti et al.
Blood, 130(17), 1934-1945 (2017-08-05)
Cellular iron homeostasis is controlled by the iron regulatory proteins (IRPs) 1 and 2 that bind cis-regulatory iron-responsive elements (IRE) on target messenger RNAs (mRNA). We identified profilin 2 (Pfn2) mRNA, which encodes an actin-binding protein involved in endocytosis and
Kenny Schlosser et al.
Thorax, 73(3), 248-261 (2017-09-28)
Elevated plasma levels of angiopoietin-2 (ANGPT2) have been reported in patients with acute lung injury (ALI); however, it remains unclear whether this increase contributes to, or just marks, the underlying vasculopathic inflammation and leak associated with ALI. Here we investigated

Contenuto correlato

The angiogenesis pathway is complex with many targets to analyze. Simultaneous quantification of multiple markers, with the MILLIPLEX® Human Angiogenesis/Growth Factor Panel 1, saves valuable resources. See how this panel was used to correlate angiogenesis biomarkers with early metastatic progression in NSCLC.

Detection of cancer biomarkers through multiplex cancer assays can accelerate studies of normal homeostasis and tumorigenic processes. See how MILLIPLEX® multiplex cancer assays are advancing various cancer research areas including lung cancer, breast cancer, and immuno-oncology research.

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