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Key Documents

MABT129

Sigma-Aldrich

Anti-VE-Cadherin Antibody (CD144), clone BV9

clone BV9, from mouse

Sinonimo/i:

Cadherin-5, 7B4 antigen, Vascular endothelial cadherin, VE-cadherin, CD144

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

Forma dell’anticorpo

purified antibody

Tipo di anticorpo

primary antibodies

Clone

BV9, monoclonal

Reattività contro le specie

human

tecniche

activity assay: suitable
immunocytochemistry: suitable

Isotipo

IgG2aκ

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... CDH5(1003)

Descrizione generale

Also known as CD144, human Vascular Endothelial (VE)-cadherin is a calcium-dependent adhesion molecule strictly located at cell to cell junctions. VE-cadherin is present in all types of endothelium (veins, arteries, capillary and large vessels). Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherins are reported to play an important role in angiogeneis and in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha catenin forming a link to the cytoskeleton.

Specificità

This antibody recognizes the extracellular domain of VE-Cadherin.

Immunogeno

Epitope: Extracellular domain.
Recombinant protein corresponding to the extracellular domain of human VE-Cadherin.

Applicazioni

Activity Assay Analysis: A representative lot from an independent laboratory increased endothelial permeability, inhibited the organization of vasclular-like structures, and prevented the protective effect of VEGF against apoptosis in endothelial cells.
Research Category
Cell Structure
Research Sub Category
Adhesion (CAMs)
This VE-Cadherin antibody is validated for use in ICC & Enzyme Assay for the detection of the VE-Cadherin protein.

Qualità

Evalutated by Immunocytochemistry in HUVEC cells.

Immunocytochemistry Analysis: 1 µg/mL of this antibody detected VE-Cadherin in HUVEC cells.

Descrizione del bersaglio

88 kDa calculated

Stato fisico

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2aκ in buffer containing PBS without 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Risultati analitici

Control
HUVEC cells

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Raccomandato

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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A novel endothelial-specific membrane protein is a marker of cell-cell contacts.
Lampugnani, MG; Resnati, M; Raiteri, M; Pigott, R; Pisacane, A; Houen, G; Ruco, LP; Dejana, E
The Journal of cell biology null
L Caveda et al.
The Journal of clinical investigation, 98(4), 886-893 (1996-08-15)
Endothelial cell proliferation is inhibited by the establishment of cell to cell contacts. Adhesive molecules at junctions could therefore play a role in transferring negative growth signals. The transmembrane protein VE-cadherin (vascular endothelial cadherin/cadherin-S) is selectively expressed at intercellular clefts
Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin.
Breviario, F; Caveda, L; Corada, M; Martin-Padura, I; Navarro, P; Golay, J; Introna et al.
Arteriosclerosis, Thrombosis, and Vascular Biology null
Monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate endothelial permeability.
Corada, M; Liao, F; Lindgren, M; Lampugnani, MG; Breviario, F; Frank, R; Muller et al.
Blood null
Cécile Otten et al.
EMBO molecular medicine, 10(10) (2018-09-06)
Cerebral cavernous malformations (CCMs) are vascular lesions in the central nervous system causing strokes and seizures which currently can only be treated through neurosurgery. The disease arises through changes in the regulatory networks of endothelial cells that must be comprehensively

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