MABC147

Anti-TRAIL/CD253 Antibody, clone 6D12.2

clone 6D12.2, from mouse

• Sinonimo/i: Tumor necrosis factor ligand superfamily member 10, Apo-2 ligand, Apo-2L, TNF-related apoptosis-inducing ligand, Protein TRAIL, CD253
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: 6D12.2, monoclonal
• Reattività contro le specie: human
• tecniche: flow cytometry: suitable; immunohistochemistry: suitable
• Isotipo: IgG1κ
• N° accesso NCBI: NP_001177871
• N° accesso UniProt: P50591
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... TNFSF10(8743)

Descrizione

Descrizione generale

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel member in the TNF family was recently identified and designated TRAIL (for TNF-related apoptosis-inducing ligand) and Apo-2L (for Apo-2 ligand). TRAIL is a type II membrane protein and is expressed in a variety of human tissues. Two novel death domain containing receptors DR4 and DR5 have been identified as the receptor for TRAIL. Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kB activation in many tissues and cells.

Immunogeno

GST-tagged recombinant protein corresponding to human TRAIL/CD253.

Applicazioni

Anti-TRAIL/CD253 Antibody, clone 6D12.2 is an antibody against TRAIL/CD253 for use in flow cytometry & IHC.

Flow Cytometry Analysis: 4 µg of this antibody detected TRAIL/CD253 in 1X10E6 human PBMC, which were treated with a proinflammatory stimulus.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TRAIL/CD253 in human prostate cancer sections. (Note: This antibody detects TRAIL/CD253 in cancer tissues and not in normal tissues.).

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Qualità

Evaluated by Flow Cytometry in HeLa cells, which were treated with a proinflammatory stimulus.

Flow Cytometry Analysis: 4 µg of this antibody detected TRAIL/CD253 in 1X10E6 HeLa cells, which were treated with a proinflammatory stimulus.

Descrizione del bersaglio

33 kDa calculated

Stato fisico

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable