IL029
Interleukin-12 Protein, Recombinant human
The recombinant human Interleukin-12 protein (or IL-12 protein) is a potent regulator of cell mediated immune responses & it induces IFN-gamma production by NK & T cells.
Sinonimo/i:
IL-12
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About This Item
Codice UNSPSC:
12352202
eCl@ss:
32160405
NACRES:
NA.77
Prodotti consigliati
Origine biologica
human
Livello qualitativo
Ricombinante
expressed in CHO cells
Saggio
>98% (SDS-PAGE and HPLC)
Attività specifica
≥1.0 x 10E6 U/mg
Produttore/marchio commerciale
Chemicon®
tecniche
cell culture | mammalian: suitable
Impurezze
<0.1 ng/μg endotoxin (of IL-12; 1EU/μg)
input
sample type hematopoietic stem cell(s)
Condizioni di spedizione
dry ice
Descrizione generale
Interleukin-12 (IL-12) is a potent regulator of cell mediated immune responses and it induces IFN-gamma production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes, and connective tissue type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-gamma producing Th1 cells. Human IL-12 is a disulfide linked heterodimeric protein with a molecular weight of 75 kDa comprised of disulfide-bonded 35 kDa (p35) and 40 kDa (p40) subunits.
Product Source: CHO cells (Chinese Hamster Ovarian cells)
Applicazioni
For most in vitro applications, IL-12 exerts its biological activity in the concentration range of 1.0 to 10.0 ng/mL.
Azioni biochim/fisiol
The ED50 as determined by the induction of IFN-g production from NK cells co-stimulated with IL-18 was ≤ 1.0 ng/mL
Stato fisico
The sterile filtered solution was lyophilized from 0.5X PBS pH 7.2
Stoccaggio e stabilità
The lyophilized IL-12, though stable at room temperature, is best stored desiccated below 0°C. Reconstitute with sterile water to a concentration of 0.2 mg/mL. Reconstituted IL-12 should be stored in undiluted aliquots at -20°C for up to 6 months.
Note legali
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
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