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Merck
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Documenti fondamentali

EZHPI

Millipore

Human Proinsulin ELISA Kit

measures and quantifies Proinsulin levels in 20 μL serum or plasma

Sinonimo/i:

Human Proinsulin Detection, Proinsulin ELISA

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About This Item

Codice UNSPSC:
12161503
eCl@ss:
32161000
NACRES:
NA.32

Nome del prodotto

Human Total Proinsulin ELISA, This Human Total Proinsulin ELISA is used to measure & quantify Proinsulin levels in Metabolism & Endocrine & Cell Signaling research.

Livello qualitativo

200

Reattività contro le specie

human

Confezionamento

kit of 1 × 96 wells

Parametri

20 μL sample volume (4hr assay)

assay range

accuracy: 88-103%
linearity: 84-120%
sensitivity: 0.5 pM
standard curve range: 2-200 pM

tecniche

ELISA: suitable

input

sample type serum
sample type plasma (K2 EDTA)

N° accesso NCBI

NM_000207.2

N° accesso UniProt

P01308

applicazioni

research use

Metodo di rivelazione

colorimetric (450nm)

Condizioni di spedizione

wet ice

Temperatura di conservazione

2-8°C

Descrizione generale

Proinsulin, the precursor of insulin and C-peptide, is made by the β cells of the pancreas. Proinsulin formed by the cleavage of pre-proinsulin contains B- and A-domains linked through the connecting domain. Proinsulin interacts with insulin receptor-A (IR-A) isoform present in the nervous system and exhibits antiapoptotic and neuroprotective effects in the developing and postnatal nervous system. Elevated levels of proinsulin serve as a marker for secretory β-cell dysfunction. Increased levels of this hormone are also observed in patients with type 2 diabetes and impaired glucose tolerance. This kit measures the intact and intermediate metabolic forms of human proinsulin.

Applicazioni

Human Total Proinsulin ELISA has been used to measure plasma, serum, eye, and retinal levels of human proinsulin.

Altre note

Research Sub Category
Obesity
Metabolic Disorders
Research Category
Metabolism
20 μL sample volume 3 hour assay, room temperature

Esclusione di responsabilità

For research use only. Not for use in diagnostic procedures.

Pittogrammi

CorrosionExclamation mark
GHS05,GHS07

Avvertenze

Warning

Indicazioni di pericolo

H290,H317

Classi di pericolo

Met. Corr. 1 - Skin Sens. 1

Codice della classe di stoccaggio

8A - Combustible corrosive hazardous materials

Certificati d'analisi (COA)

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Michael A Weiss
The Journal of biological chemistry, 284(29), 19159-19163 (2009-04-28)
Insulin plays a central role in the regulation of vertebrate metabolism. The hormone, the post-translational product of a single-chain precursor, is a globular protein containing two chains, A (21 residues) and B (30 residues). Recent advances in human genetics have
Carolina Isiegas et al.
Investigative ophthalmology & visual science, 57(8), 3610-3618 (2016-07-09)
The induction of proinsulin expression by transgenesis or intramuscular gene therapy has been shown previously to retard retinal degeneration in mouse and rat models of retinitis pigmentosa (RP), a group of inherited conditions that result in visual impairment. We investigated
Flora de Pablo et al.
Frontiers in molecular neuroscience, 11, 426-426 (2018-12-12)
Proinsulin was first identified as the primary translation product of the insulin gene in Donald Steiner's laboratory in 1967, and was the first prohormone to be isolated and sequenced. While its role as an insulin precursor has been extensively studied

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