ABE1081

Anti-JMJD2E/KDM4E Antibody

serum, from rabbit

• Sinonimo/i: Lysine-specific demethylase 4E, KDM4D-like protein, Lysine-specific demethylase 4D-like, JMJD2E
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Forma dell’anticorpo: serum
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Reattività contro le specie: mouse, rat, human
• tecniche: western blot: suitable
• N° accesso NCBI: XP_004052044
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... KDM4E(390245)

Descrizione

Descrizione generale

Histone N(ϵ)-methyl lysine demethylases are important in epigenetic regulation. JMJD2E (KDM4E) also known as Lysine-specific demethylase 4E, histone lysine demethylase 4E, or KDM4D-like protein, and encoded by the gene KDM4E/KDM4DL, is a member of the large Fe(II)/2-oxoglutarate- dependent family of human histone demethylases. JMJD2E (KDM4E) is a histone demethylase that specifically demethylates ′Lys-9′ of histone H3, thereby playing a central role in histone code. The KDM4 family also includes KDM4A, KDM4B, KDM4C, and KDM4D. These are also referred to as JMDM3A/JMJD2A, JMDM3B/JMJD2B, JMDM3C/JMJD2C, and JMDM3D/JMJD2D, respectively. Steady-state assays showed that KDM4E has a graded response to O2 over a physiologically relevant range of O2 concentrations, with activity level being dependent upon the methylation status of the target protein, and research with JMJD2E(KDM4E) may indicate the potential for histone demethylase activity to be regulated by oxygen availability.

Immunogeno

Linear peptide corresponding to JMJD2E/KDM4E.

Applicazioni

Detect JMJD2E/KDM4E using this Anti-JMJD2E/KDM4E antibody validated for use in western blotting.

Qualità

Evaluated by Western Blotting in PC-12 cell lysate.

Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected JMJD2E/KDM4E in 10 µg of PC-12 cell lysate.

Descrizione del bersaglio

~65 kDa observed

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1