AB5128
Anti-Melanocortin Receptor-2 Antibody
Chemicon®, from rabbit
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Purificato mediante
affinity chromatography
Reattività contro le specie
mouse, rat, human
Produttore/marchio commerciale
Chemicon®
tecniche
ELISA: suitable
western blot: suitable
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
dry ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... MC2R(4158)
Descrizione generale
Mouse Melanocortin receptor 2 (MC2-R or ACTH-R) is a 297 aa transmembrane protein belonging to the family of G-Protein coupled receptors. It is a receptor for ACTH. It is found in melanocyte and corticoadrenal tissues. Defects in insensitivity or resistance to ACTH and characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency.
Immunogeno
A 17 aa peptide (designated MCR21) from the 4th cytoplasmic domain of mouse MC2-R.
Applicazioni
Research Category
Neuroscience
Neuroscience
Research Sub Category
CNS Control of Metabolism
Hormones & Receptors
CNS Control of Metabolism
Hormones & Receptors
This Anti-Melanocortin Receptor-2 Antibody is validated for use in ELISA, WB for the detection of Melanocortin Receptor-2.
Western blot: 1-10 μg/mL using Chemiluminescence technique
ELISA: 1:10,000 - 100,000
Optimal working dilutions must be determined by end user.
ELISA: 1:10,000 - 100,000
Optimal working dilutions must be determined by end user.
Stato fisico
Affinity Purified 1mg/mL solution in PBS, with 0.1% BSA.
Stoccaggio e stabilità
Can be refrigerated at 2-8°C in undiluted aliquots for short term use. Maintain frozen at -20°C in undiluted aliquots for up to 12 months.
Altre note
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Note legali
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
M Kubo et al.
Gene, 153(2), 279-280 (1995-02-14)
A genomic DNA encoding a mouse adrenocorticotropin (ACTH) receptor was isolated. The predicted 296-amino-acid sequence showed 88.9 and 78.7% identities to the human and bovine homologues, respectively.
C Tsigos et al.
The Journal of clinical investigation, 92(5), 2458-2461 (1993-11-01)
Isolated glucocorticoid deficiency (IGD) is an autosomal recessive disorder characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency. The cDNA and gene of the human ACTH receptor were recently cloned. The gene encodes a 297-amino acid protein that belongs to
M Raikhinstein et al.
Biochimica et biophysica acta, 1220(3), 329-332 (1994-02-17)
We isolated five independent cDNAs of nearly 3000 bp for the bovine ACTH receptor by screening adrenal cortex cDNA libraries with a PCR cloned cDNA fragment. The deduced receptor sequence includes 297 residues (M(r) = 33,258) with 81% identity with
A J Clark et al.
Lancet (London, England), 341(8843), 461-462 (1993-02-20)
Familial glucocorticoid deficiency is an uncommon disorder that appears to be due to congenital insensitivity or resistance to adrenocorticotropin (ACTH), and is usually inherited in an autosomal recessive pattern. We investigated the DNA base sequence in a family with this
Voluntary wheel running initially increases adrenal sensitivity to adrenocorticotrophic hormone, which is attenuated with long-term training.
Campbell, JE; Rakhshani, N; Fediuc, S; Bruni, S; Riddell, MC
Journal of Applied Physiology (1985)
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