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Key Documents

AB3232

Sigma-Aldrich

Anti-Low Density Lipoprotein Antibody, HOCL oxidized

serum, Chemicon®

Sinonimo/i:

LDL

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

Forma dell’anticorpo

serum

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Reattività contro le specie

human

Produttore/marchio commerciale

Chemicon®

tecniche

ELISA: suitable
immunohistochemistry: suitable

Condizioni di spedizione

dry ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... LDLR(3949)

Specificità

Reacts strongly and very specifically with HOCL-LDL. By time resolved fluorescence there was no detectable cross reactivity to unmodified LDL has been observed. However weak cross reactivity with MDA-LDL (20%), HNE-LDL (5%) and minimally modified LDL (5%) was observed. By Western blot no detectable cross reactivity to unmodified LDL was observed. Weak cross reactivity (<10%) was detected with MDA-LDL, HNE-LDL and 24 hour Cu2+ oxidized LDL. By ELISA the antibody bound to early and late stages of HOCL-LDL but only weakly (<5%) to several other modifications including MDA-LDL, Cu2-ox-LDL, MDA-HSA and native LDL.

Immunogeno

Epitope: HOCL oxidized
Hypochlorite-modified LDL.

Applicazioni

Immunohistochemistry: 1:50-1:400

ELISA: 1:400-1:4,000

Optimal working dilutions must be determined by the end user.
Research Category
Metabolism
Research Sub Category
Lipid Metabolism & Weight Regulation
This Anti-Low Density Lipoprotein Antibody, HOCL oxidized is validated for use in ELISA, IH for the detection of Low Density Lipoprotein.

Stato fisico

Rabbit serum.

Stoccaggio e stabilità

Maintain lyophilized material at -20°C for up to 6 months After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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LOX-1 mediates vascular lipid retention under hypertensive state.
Nakano A, Inoue N, Sato Y, Nishimichi N, Takikawa K, Fujita Y, Kakino A, Otsui K et al.
Journal of Hypertension null
Feng-Shiun Shie et al.
The American journal of pathology, 164(4), 1173-1181 (2004-03-25)
Ischemic injury to brain is associated with both disruption of the blood-brain barrier and increased oxidative stress. Given the neurotoxicity associated with exposure to oxidized low-density lipoprotein (oxLDL) in vitro, we tested the hypothesis that oxLDL may be present in

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