8.55070

HMBA-PEGA resin

Novabiochem^®

• Sinonimo/i: 4-Hydroxymethylbenzoic acid PEGA resin
• Codice UNSPSC: 51171641
• NACRES: NA.22

Proprietà

• Livello qualitativo: 200
• Nome Commerciale: Novabiochem^®; PEGA
• Forma fisica: beads
• Impiego in reazioni chimiche: reaction type: Fmoc solid-phase peptide synthesis
• Produttore/marchio commerciale: Novabiochem^®
• applicazioni: peptide synthesis
• Gruppo funzionale: alcohol
• Temperatura di conservazione: 2-8°C

Descrizione

Descrizione generale

This support consists of amino PEGA resin derivatized with Sheppard′s base-labile 4-hydroxymethylbenzoic acid linker ^[1]. For further information, please refer to the product entry for amino PEGA resin(855015). Note: PEGA resins are supplied swollen in ethanol, with 1g dry resin corresponding to approximately 15 mL of swollen resin. As the beads of PEGA resins become very sticky and easily damaged when shrunk or dried, they are best handled in a swollen state. To use, the appropriate amount of swollen resin should be weighed into a reaction vessel and any residual ethanol removed by copious washings with the appropriate solvent or solvent mixture. After peptide assembly, the resin should be washed with DCM and transferred to the cleavage vessel. Excess DCM can be removed under vacuum, and the shrunk resin treated with the TFA cocktail. The characteristics of the swollen resin, its robustness and high permeability enables its use in both batch and continuous flow synthesis apparatus.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

^[1] R. C. Sheppard, et al. (1982) Int. J. Peptide Protein Res., 20, 451.

Linkage

Replaces: 01-64-0113

Risultati analitici

Colour (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.10 - 0.40 mmol/g
Swelling Volume (in DMF): lot specific result
dry resin %: lot specific result
The resin is sold swollen in ethanol.

Note legali

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable