610225

Tigecycline

A broad-spectrum glyclcycline class of antimicrobial agent that is active against both Gram positive and Gram negative bacteria.

• Sinonimo/i: Tigecycline, 9- t-Butylglycylamido-minocycline, 9-t-Butylglycylamido-minocycline
• Formula empirica (notazione di Hill): C₂₉H₃₉N₅O₈
• Numero CAS: 220620-09-7
• Peso molecolare: 585.65
• Numero MDL: MFCD00935753
• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 100
• Saggio: ≥99% (HPLC)
• Stato: powder
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: orange
• Solubilità: DMSO: soluble
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O=C(C1=C(O)[C@@](C(C(C(N)=O)=C(O)[C@H]2N(C)C)=O)(O)[C@@]2([H])C[C@]1([H])C3)C4=C3C(N(C)C)=CC(NC(CNC(C)(C)C)=O)=C4O
• InChI: 1S/C29H39N5O8/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36/h10,12,14,21,31,36-37,41-42H,8-9,11,30H2,1-7H3,(H,32,35)/b27-20-/t12-,14-,21-,29-/m0/s1; ZXGBRIBPJBHLMO-SBMFAFPZSA-N

Descrizione

Descrizione generale

A broad-spectrum glyclcycline class of antimicrobial agent that is active against both Gram positive and Gram negative bacteria. Exhibits toxicity for human AML cells at all stages of development in both in vitro and in vivo models. Selectively kills leukemic stem and progenitor cells (LD₅₀ ~10 µM) and reduces the repopulating ability of the primary AML cells while sparing normal hematopoietic cells. Its action on growth and viability of eukaryotic cells is shown to be due to its inhibitory effects on mitochondrial protein translation and respiratory complex activity.

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Irritant (B)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Skrtic, M., et al. 2011. Cancer Cell20, 674.
Olson, M.W., et al. 2006. Antimicrob. Agents Chemother.50, 2156.
Stein, G.E., and Craig, W.A., 2006. Clin. Infect Dis.43, 518.
Livermore, D.M., 2005. J. Antimicrob. Chemother.56, 611.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS05,GHS07,GHS09
• Avvertenze: Danger
• Indicazioni di pericolo: H317,H318,H360FD,H410
• Consigli di prudenza: P202 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classi di pericolo: Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Repr. 1B - Skin Sens. 1
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable