559397

SB 202190

InSolution, ≥98%, p38 MAP kinase inhibitor

• Sinonimo/i: InSolution SB 202190, InSolution p38 MAP Kinase Inhibitor II
• Formula empirica (notazione di Hill): C₂₀H₁₄FN₃O
• Numero CAS: 152121-30-7
• Peso molecolare: 331.34
• Numero MDL: MFCD00941964
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: liquid
• Potenza: 16 nM IC₅₀; 16 nM K_i
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• InChI: 1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,23-24H; NJNKPVPFGLGHPA-UHFFFAOYSA-N

Descrizione

Descrizione generale

A potent and cell-permeable inhibitor of p38 MAP kinase. Inhibits p38 phosphorylation of myelin basic protein (MBP) with no effect on the activity of the ERK or JNK MAP kinase subgroups. Also inhibits the kinase activity of p38β (IC₅₀ = 350 nM) and p38 phosphorylation of activating transcription factor 2 (ATF-2; IC₅₀ = 280 nM). Blocks LPS-induced TNF-α and interleukin biosynthesis. Reported to block LDL expression in Hep52 cells.

Azioni biochim/fisiol

Cell permeable: yes

Primary Target
P38β

Product competes with ATP.

Reversible: yes

Target K_i: 350 nM against the kinase activity of p38β; 280 nM against p38 phosphorylation of activating transcription factor 2 (ATF-2)

Confezionamento

Packaged under inert gas

Please refer to vial label for lot-specific concentration.

Attenzione

Toxicity: Irritant (B)

Stato fisico

A 1 mg/ml solution of SB 202190 (Cat. No. 559388) in anhydrous DMSO.

Ricostituzione

Following initial thaw, aliquot and freeze (-20°C).

Altre note

Ajizian, S.J., et al. 1999. J. Infect. Dis.179, 939.
Singh, R.P., et al. 1999. J. Biol. Chem.274, 19593.
Wang, S.W., et al. 1999. Inflamm. Res.48, 533.
Gallagher, T.F., et al. 1997. Bioorg. Med. Chem.5, 49.
Jiang, Y., et al. 1996. J. Biol. Chem.271, 17920.
Kramer, R.M., et al. 1996. J. Biol. Chem.271, 27723.
Li, Z., et al. 1996. Biochem. Biophys. Res. Commun.228, 334.
Lee, L.C., et al. 1994. Nature372, 739.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• Punto d’infiammabilità (°C): 87 °C - closed cup - (Dimethylsulfoxide)