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5291

Sigma-Aldrich

Polymyxin B Sulfate

Polymyxin B Sulfate, CAS 1405-20-5, is an antibiotic that is effective against Gram-positive bacteria. Inhibits phospholipid-sensitive Ca2+-dependent protein kinases.

Sinonimo/i:

Polymyxin B Sulfate, Aerosporin

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About This Item

Numero CAS:
1405-20-5
Numero MDL:
MFCD00131991
Codice UNSPSC:
12352200
NACRES:
NA.77

Livello qualitativo

200

Forma fisica

solid

Produttore/marchio commerciale

Calbiochem®

Condizioni di stoccaggio

OK to freeze

Colore

white to off-white

Solubilità

water: 25 mg/mL

Condizioni di spedizione

ambient

Temperatura di conservazione

10-30°C

InChI

1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
HNDFYNOVSOOGDU-UHFFFAOYSA-N

Descrizione generale

Polymyxin B is a polypeptide antibacterial that belongs to the polymyxin family. It exerts its effects against Gram-negative bacteria such as Pseudomonas aeruginosa, Acinetobacter baumannii, Enterobacter sp., and Klebsiella sp.. Polymyxin B sulfate is a mixture of polymyxin B1 sulfate and polymyxin B2 sulfate.

Applicazioni

Polymyxin B Sulfate - CAS 1405-20-5 – Calbiochem has been used:
  • to neutralize the endotoxins in bovine serum albumin
  • in the in vitro treatment of hepatic stellate cells (HSCs)
  • as an antibiotic in collateral sensitivity and cross-resistance analysis in Escherichia coli

Azioni biochim/fisiol

Polymyxin B possesses antiendotoxin activity. It binds to lipid A of the lipopolysaccharide (LPS) molecules and facilitates penetration by displacing Ca2+ and Mg2+ in the outer membrane of Gram-negative bacteria.

Attenzione

Toxicity: Harmful (C)

Altre note

Lucas, M., et al. 1994. Biochem. Pharmacol. 47, 667.
Ngezahayo, A. and Kolb, H.A. 1993. Pflugers Arch.422, 413.
Kubo, M. and Okada, Y. 1992. J. Physiol.456, 351.
Strasser, S.H., et al. 1992. Circ. Res.70, 1304.
Hegemann, L., et al. 1991. Eur. J. Pharmacol.207, 17.
Inaba, H. and Filkins, J.P. 1991. Am. J. Physiol.261, R26.
Marra, M.N., et al. 1990. J. Immunol.144, 662.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Polymyxin B solution 1 mg/mL in H2O, analytical standard

Supelco

81271

Polymyxin B solution

Polymyxin B selective supplement for bacteria, sterile, suitable for microbiology

Millipore

P9602

Polymyxin B selective supplement

USP

USP

1235503

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Polymyxin B nonapeptide hydrochloride cationic cyclic peptide

Sigma-Aldrich

P2076

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Bacteria in nature often encounter non-antibiotic antibacterials (NAAs), such as disinfectants and heavy metals, and they can evolve resistance via mechanisms that are also involved in antibiotic resistance. Understanding whether susceptibility to different types of antibacterials is non-randomly associated across
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Hyaluronan (HA), a major extracellular matrix glycosaminoglycan, is a biomarker for cirrhosis. However, little is known about the regulatory and downstream mechanisms of HA overproduction in liver fibrosis. Hepatic HA and HA synthase 2 (HAS2) expression was elevated in both

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