525145

sPLA₂-IIA Inhibitor I

The sPLA₂-IIA Inhibitor I controls the biological activity of sPLA₂-IIA. This small molecule/inhibitor is primarily used for Cell Signaling applications.

• Sinonimo/i: sPLA₂-IIA Inhibitor I, c(2NapA)LS(2NapA)R, TFA
• Formula empirica (notazione di Hill): C₄₁H₅₀N₈O₆ · xC₂HF₃O₂
• Peso molecolare: 750.89 (free base basis)
• Codice UNSPSC: 41106300
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95% (HPLC)
• Forma fisica: lyophilized solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated (hygroscopic)
• Colore: white
• Solubilità: DMSO: 5 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C

Descrizione

Descrizione generale

A highly hydrophobic cyclic pentapeptide that selectively binds and acts as a potent inhibitor of human type IIA secreted phospholipase A₂ (sPLA₂-IIA) (IC₅₀ = 12.8 µM). Reported to effectively block sPLA₂-IIA-induced PGE₂ production at 100 nM in human rheumatoid synoviocytes and is non-toxic at doses up to 10 µM. Does not have any significant effect on the activities of porcine sPLA₂-IB, Naja naja sPLA₂-IB, or Crotalus durissus sPLA₂-IIA at 10 µM.

A highly hydrophobic cyclic pentapeptide that selectively binds and acts as a potent inhibitor of sPLA₂-IIA (human type IIA secreted phospholipase A₂; IC₅₀ = 12.8 μM). Shown to effectively block sPLA₂-IIA-induced PGE₂ production at 100 nM in human rheumatoid synoviocytes and is non-toxic at doses up to 10 μM. Does not have any significant effect on the activities of porcine sPLA₂-IB, Naja naja sPLA₂-IB, or Crotalus durissus sPLA₂-IIA even at 10 μM concentration.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
sPLA2-IIA (human type IIA secreted phospholipase A2

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 12.8 µM against sPLA2-IIA (human type IIA secreted phospholipase A2

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Sequenza

cyclic(2-NaphthylAla-Leu-Ser-2-NaphthylAla-Arg)•TFA

Altre note

Church, W.B., et al. 2001. J. Biol. Chem.276, 33156.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable