5.09612

TAPI-2

InSolution, ≥97%, 10 mM aqueous solution, inhibitor of matrix metalloproteinases and TACE (TNF-α convertase; ADAM17)

• Sinonimo/i: InSolution TAPI-2
• Formula empirica (notazione di Hill): C₁₉H₃₇N₅O₅
• Numero CAS: 187034-31-7
• Peso molecolare: 415.53
• Numero MDL: MFCD00040626
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥97% (HPLC)
• Stato: liquid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Temperatura di conservazione: −70°C

Descrizione

Descrizione generale

A hydroxamate-based inhibitor of matrix metalloproteinases and TACE (TNF-α convertase; ADAM17). Inhibits the activation-dependent shedding of L-selectin from neutrophils, eosinophils, and lymphocytes as well as phenylarsine oxide (PAO)-induced shedding in neutrophils. Also blocks the shedding of several cell surface proteins such as pro-TGF-α, IL-6 receptor α-subunit, and β-amyloid precursor protein. Reported to inhibit TNF-α release and impart protection against aspirin-induced gastric mucosal injury. Acts as a weak inhibitor of angiotensin converting enzyme (IC₅₀ = 18 µM).

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Stato fisico

A 10 mM (1 mg/241 µL) sterile-filtered solution of TAPI-2 (Cat. No. 579052) in H₂O.

Ricostituzione

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C.

Altre note

Bennett, T.A., et al. 2000. J. Immunol.164, 4120.
Fiorucci, S., et al. 1998. Aliment. Pharmacol. Ther.12, 1139.
Hooper, N.M., et al. 1997. Biochem. J.321, 265.
Parvathy, S., et al. 1997. Biochem. J.327, 37.
Arribas, J., et al. 1996. J. Biol. Chem.271, 11376.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany