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Documenti fondamentali

487928

Sigma-Aldrich

Nocodazole

≥99% (HPLC), solid, microtuble inhibitor, Calbiochem

Sinonimo/i:

Nocodazole, R17934, Methyl-[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamate

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About This Item

Formula empirica (notazione di Hill):
C14H11N3O3S
Numero CAS:
31430-18-9
Peso molecolare:
301.32
Numero MDL:
MFCD00005588
Codice UNSPSC:
12352200
NACRES:
NA.77

Nome del prodotto

Nocodazole, Inhibitor of mitosis.

Livello qualitativo

100

Descrizione

RTECS - DD6521000

Saggio

≥99% (HPLC)

Stato

solid

Produttore/marchio commerciale

Calbiochem®

Condizioni di stoccaggio

OK to freeze

Colore

pale yellow

Solubilità

DMSO: 5 mg/mL

Condizioni di spedizione

ambient

Temperatura di conservazione

10-30°C

Stringa SMILE

[s]1c(ccc1)C(=O)c2cc3nc([nH]c3cc2)NC(=O)OC

InChI

1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)
KYRVNWMVYQXFEU-UHFFFAOYSA-N

Descrizione generale

Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also available as a 50 mM solution in DMSO (Cat. No. 487929).

Azioni biochim/fisiol

Cell permeable: no
Primary Target
Promotes tubulin depolymerization
Product does not compete with ATP.
Reversible: no

Attenzione

Toxicity: Carcinogenic / Teratogenic (D)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 year at -20°C.

Altre note

Park, H., et al. 2011. Chem. Med. Chem.in press.
Bunz, F., et al. 1998. Science 282, 1497.
Fleischman, L.F., et al. 1993. Oncogene8, 771.
Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun.189, 1429.
Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci.103, 1167.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pittogrammi

Health hazard
GHS08

Avvertenze

Warning

Indicazioni di pericolo

H341,H361d

Classi di pericolo

Muta. 2 - Repr. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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