476480

PKC 20-28, Cell-Permeable, Myristoylated

Pseudosubstrate sequence from protein kinase Cα and β ( PKCα and PKCβ).

• Sinonimo/i: PKC 20-28, Cell-Permeable, Myristoylated, Myr-N-FARKGALRQ-NH₂, Myristoylated Protein Kinase C Inhibitor 20-28, Cell-Permeable, Protein Kinase C 20-28, Cell-Permeable, Myristoylated, Myristoylated Protein Kinase C Inhibitor 20-28, Cell-Permeable, Myr-N-FARKGALRQ-NH₂, Protein Kinase C 20-28, Cell-Permeable, Myristoylated
• Formula empirica (notazione di Hill): C₆₀H₁₀₆N₁₈O₁₁
• Peso molecolare: 1255.60
• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95% (HPLC)
• Forma fisica: lyophilized solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated (hygroscopic)
• Solubilità: water: 10 mg/mL; Tris-HCl, pH 7.5: 25 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C

Descrizione

Descrizione generale

Pseudosubstrate sequence from protein kinase C_α and β ( PKC_α and PKC_β). N-Terminus is myristoylated to allow membrane permeability. Highly specific, reversible, and substrate competitive inhibitor of TPA activation of MARCKS phosphorylation in fibroblast primary cultures (IC₅₀ = 8 µM); exhibits 98% inhibition at 100 µM.

Pseudosubstrate sequence from protein kinase Ca (PKC_α) and PKC_β. N-terminal myristoylated to allow membrane permeability. Highly specific, reversible, and substrate competitive inhibitor of TPA activation of MARCKS phosphorylation in fibroblast primary cultures (IC₅₀ = 8 µM). Exhibits 98% inhibition at 100 µM.

Azioni biochim/fisiol

Cell permeable: yes

Primary Target
TPA activation of MARCKS phosphorylation in fibroblast primary cultures

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 8 µM against TPA activation of MARCKS phosphorylation in fibroblast primary cultures

Confezionamento

Yes

Attenzione

Toxicity: Standard Handling (A)

Sequenza

N-Myr-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-NH₂

Altre note

Eichholtz, T., et al. 1993. J. Biol. Chem. 268, 1982.
Ward, N.E. and O’Brian, C.A. 1993. Biochemistry32, 11903.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable