454575

N-Methyl-D-aspartic Acid hydrate

>95% (TLC), solid, excitatory amino acid neurotransmitter, Calbiochem^®

• Sinonimo/i: N-Methyl-D-aspartic Acid, Hydrate, NMDA
• Formula empirica (notazione di Hill): C₅H₉NO₄ · xH₂O
• Numero CAS: 6384-92-5
• Peso molecolare: 147.13 (anhydrous basis)
• Numero MDL: MFCD00004226
• Codice UNSPSC: 12352209
• NACRES: NA.77

Proprietà

• Nome del prodotto: N-Methyl-D-aspartic Acid, Hydrate, Excitatory amino acid neurotransmitter.
• Livello qualitativo: 100
• Descrizione: Merck USA index - 14, 6662
• Saggio: >95% (TLC)
• Stato: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze
• Colore: white
• Solubilità: water: 1 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 10-30°C
• Stringa SMILE: N([C@H](CC(=O)O)C(=O)[O-])C
• InChI: 1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/p-1/t3-/m1/s1; HOKKHZGPKSLGJE-GSVOUGTGSA-M

Descrizione

Descrizione generale

An excitatory amino acid neurotransmitter. Selective agonist of the glutamate receptor that regulates Ca²⁺ channels. Important in long-term potentiation, ischemia, and epilepsy. NMDA receptors are involved in the "fine tuning" of synaptic connections in the developing brain. Chronic treatment with NMDA produces structural changes in synaptic morphology. Over-excitation of NMDA receptors causes neuronal degeneration and cell death.

Excitatory amino acid neurotransmitter. Selective agonist of the glutamate receptor that regulates Ca²⁺ channels. Important in long-term potentiation, ischemia, and epilepsy. NMDA receptors are involved in the "fine tuning" of synaptic connections in the developing brain. Chronic treatment with NMDA produces structural changes in synaptic morphology. Over-excitation of NMDA receptors causes neuronal degeneration and cell death.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
Glutamate receptor that regulates Ca2+ channels

Product does not compete with ATP.

Reversible: no

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for several days at 4°C.

Altre note

Mattson, M.P., et al. 1993. J. Neurosci. 13, 4575.
Yen, L-H., et al. 1993. J. Neurosci. 13, 4949.
Swann, J.W., et al. 1992. Epilepsy Res. Suppl. 9, 115.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable