440025

Luteolin

An antioxidant flavonoid and a free radical scavenger.

• Sinonimo/i: Luteolin, 3ʹ,4ʹ,5,7-Tetrahydroxyflavone
• Formula empirica (notazione di Hill): C₁₅H₁₀O₆
• Numero CAS: 491-70-3
• Peso molecolare: 286.24
• Numero MDL: MFCD00017309
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥90% (HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: yellow
• Solubilità: aqueous base: 1.4 mg/mL; DMSO: 7 mg/mL; ethanol: soluble
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 2-8°C
• InChI: 1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H; IQPNAANSBPBGFQ-UHFFFAOYSA-N

Descrizione

Descrizione generale

An antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T½CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G₂/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.

An antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T1/2CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G₂/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
rat liver cytosolic glutathione S-transferase activity

Product does not compete with ATP.

Reversible: no

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.

Altre note

Kim, J.E., et al. 2011. J. Pharmacol. Exp. Ther.in press.
Korkina, L.G., and Afanasev, I.B. 1997. Adv. Pharmacol.38, 151.
Plaumann, B., et al. 1996. Oncogene 13, 1605.
Ramanathan, R., et al. 1994. Free Radic. Biol. Med.16, 43.
Shimoi, L., et al. 1994. Carcinogenesis15, 2669.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable