349254

NS-398

A cell-permeable selective inhibitor of COX-2 in vitro.

• Sinonimo/i: NS-398, N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide
• Formula empirica (notazione di Hill): C₁₃H₁₈N₂O₅S
• Numero CAS: 123653-11-2
• Peso molecolare: 314.36
• Numero MDL: MFCD00882995
• Codice UNSPSC: 41121800
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (TLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze
• Colore: pale yellow
• Solubilità: DMSO: 20 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 10-30°C
• InChI: 1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3; KTDZCOWXCWUPEO-UHFFFAOYSA-N

Descrizione

Descrizione generale

A cell-permeable selective inhibitor of COX-2 in vitro. Inhibits sheep placental COX-2 (IC₅₀ = 3.8 µM) while COX-1 activity is unaffected at concentrations up to 100 µM. Displays potent anti-inflammatory and analgesic activity in vivo in rat at concentrations from 0.3 to 5 mg/kg.

A cell-permeable, selective inhibitor of cyclooxygenase-2 (COX-2) in vitro. Inhibits sheep placenta COX-2 (IC₅₀ = 3.8 µM) while COX-1 activity is completely unaffected at concentrations up to 100 µM. Displays potent anti-inflammatory and analgesic activity in vivo in rat at concentrations of 0.3 to 5 mg/kg. Does not produce any significant gastrointestinal lesions even at single oral doses of 1000 mg/kg. A useful tool to explore the role of COX-2 in physiologic and pathophysiologic processes.

Azioni biochim/fisiol

Cell permeable: yes

Primary Target
COX-2

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 3.8 µM against COX-2

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Altre note

Ouellet, M., and Percival, M.D. 1995. Biochem. J.306, 247.
Futaki, N., et al. 1994. Prostaglandins47, 55.
Arai, I., et al. 1993. Res. Comm. Chem. Pathol. Pharmacol.81, 259.
Futaki, N., et al. 1993. Gen. Pharmacol.24, 105.
Futaki, N., et al. 1993. J. Pharm.Pharmacol.45, 753.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable