343781-M

ω-Conotoxin GVIA, Conus geographus

A neurotoxin that acts as an antagonist of voltage-activated N-type Ca²⁺ channels and of neurotransmitter release at neuronal synapses.

• Sinonimo/i: ω-Conotoxin GVIA, Conus geographus, ω-CgTx GVIA
• Formula empirica (notazione di Hill): C₁₂₀H₁₈₂N₃₈O₄₃S₆
• Numero CAS: 106375-28-4
• Peso molecolare: 3037.35
• Numero MDL: MFCD00076620
• Codice UNSPSC: 12352202
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: lyophilized
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze
• Solubilità: water: 250 μg/mL; aqueous buffer: soluble
• Temperatura di conservazione: −20°C

Descrizione

Descrizione generale

A neurotoxin that acts as an antagonist of voltage-activated N-type Ca²⁺ channels and of neurotransmitter release at neuronal synapses. Its antagonistic activity is attributed to a tyrosine residue at position 13. Does not bind to dihydropyridine- or verapamil-binding sites. Also reported to inhibit ATP-induced inward currents mediated by P2X2/X3 receptors (IC₅₀ = 21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors).

Azioni biochim/fisiol

Primary Target
Voltage-activated N-type Ca2+ channels

Target IC₅₀: 21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors

Attenzione

Toxicity: Highly Toxic (H)

Sequenza

H-Cys¹-Lys-Ser-Hyp-Gly-Ser-Ser-Cys⁸-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys¹⁵-Cys¹⁶-Arg-Ser-Cys¹⁹-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys²⁶-Tyr-NH₂ (disulfide bonds: 1 → 16; 8 → 19; 15 → 26)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Altre note

Lalo, U.V., et al. 2001. Brain Res. Bull.54, 507.
Kim, J.I., et al. 1995. Biochem. Biophys. Res. Commun. 206, 449.
Abbott, J.R., and Litzinger, M.J. 1994. Int. J. Dev. Neurosci. 12, 43.
Olivera, B.M., et al. 1991. J. Biol. Chem.266, 22067.
Protti, D.A., et al. 1991. Brain Res.557, 336.
Werth, J.L., et al. 1991. Mol. Pharmacol.40, 742.
Koyano, K., et al. 1987. Eur. J. Pharmacol.135, 337.
Abe, T., et al. 1986. Neurosci. Lett.71, 203.

Note legali

Not available for sale outside of the United States.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable