238811

Cdk9 Inhibitor II

The Cdk9 Inhibitor II, also referenced under CAS 140651-18-9, controls the biological activity of Cdk9. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinonimo/i: Cdk9 Inhibitor II, 4-(3,5-Diamino-1H-pyrazol-4-ylazo)-phenol
• Formula empirica (notazione di Hill): C₉H₁₀N₆O
• Numero CAS: 140651-18-9
• Peso molecolare: 218.22
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95% (HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: orange
• Solubilità: DMSO: 10 mg/mL; ethanol: 5 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 2-8°C
• InChI: 1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15); AYZRKFOEZQBUEA-UHFFFAOYSA-N

Descrizione

Descrizione generale

A cell-permeable azo-pyrazole compound that acts as a potent, ATP-competitive, and Cdk9-selective inhibitor (IC₅₀ = 350 nM, using Cdk9/T1). It inhibits Cdk1/B, Cdk2/E, Cdk2/A, Cdk4/D1, Cdk7/H, and p70S6K only at much higher concentrations (IC₅₀ = 44, 20, 69, 13.5, 26, and 10 µM, respectively) and shows little or no activity against eight other commonly studied kinases even at concentrations as high as 10 µM. Shown to exhibit antiproliferative activity in human tumor cell lines.

Azioni biochim/fisiol

Cell permeable: yes

Primary Target
Cdk9

Product competes with ATP.

Reversible: no

Target IC₅₀: 350 nM, using Cdk9/T1

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Irritant (B)

Altre note

Krystof, V., et al. 2006. J. Med. Chem.49, 6500.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable