219365

Coagulation Factor V, Human Plasma

Coagulation Factor V, Human Plasma, CAS 9001-24-5, is a native coagulation factor V that is cleaved by thrombin to yield activated Factor Va that is 50-fold greater activity than its precursor form.

• Sinonimo/i: Coagulation Factor V, Human Plasma, Proaccelerin, Labile Factor, Ac-globulin, Ac-g
• Numero CAS: 9001-24-5
• Codice UNSPSC: 12352202
• NACRES: NA.25

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95% (SDS-PAGE)
• Stato: liquid
• Attività specifica: ≥20 units/mg protein (clotting assay)
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C

Descrizione

Descrizione generale

Native coagulation factor V from human plasma. Thrombin cleaves Factor V to yield activated Factor Va, which exhibits 50-fold greater activity than the precursor molecule. Factor Va, Ca²⁺, and membrane phospholipids are cofactors that form a "prothrombinase" complex with Factor X, enabling its proteolytic activation of prothrombin to thrombin.

Native coagulation factor V from human plasma. Thrombin cleaves Factor V to yield activated Factor Va, which exhibits 50-fold greater activity than the precursor molecule. Factor Va, Ca²⁺, and membrane phospholipids are cofactors which form a "prothrombinase" complex with Factor Xa, enabling its proteolytic activation of prothrombin to thrombin.

Confezionamento

Please refer to vial label for lot-specific concentration.

Attenzione

Toxicity: Standard Handling (A)

Stato fisico

In 50% glycerol/H₂O (v/v).

Nota sulla preparazione

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Ricostituzione

Following initial thaw, aliquot and freeze (-20°C). Do not store below -20°C.

Risultati analitici

Clotting activity is determined by comparison to a standard curve produced using normal pooled human plasma

Altre note

Walker, F.J. 1992. J. Biol. Chem.267, 19896.
Monkovic, D.D., and Tracy, P.B. 1990. J. Biol. Chem.265, 17132.
Krishnaswamy, S., et al. 1989. J. Biol. Chem.264, 3160.
Lee, C.D., and Mann, K.G. 1989. Blood73, 185.
Krieg, U.C., et al. 1987. Biochemistry26, 103.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2