215900

Carbonic Anhydrase IX/XII Inhibitor

The Carbonic Anhydrase IX/XII Inhibitor controls the biological activity of Carbonic Anhydrase IX/XII. This small molecule/inhibitor is primarily used for Cancer applications.

• Sinonimo/i: Carbonic Anhydrase IX/XII Inhibitor, CAIX Inhibitor
• Formula empirica (notazione di Hill): C₁₃H₁₂N₄O₅S
• Numero CAS: 175014-68-3
• Peso molecolare: 336.32
• Numero MDL: MFCD07097504
• Codice UNSPSC: 12352200
• NACRES: NA.54

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: white
• Solubilità: DMSO: 50 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O=C(NC1=CC=C(S(N)(=O)=O)C=C1)NC2=CC=C(N(=O)=O)C=C2

Descrizione

Descrizione generale

A cell permeable benzenesulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (K_i = 0.9 nM and 5.7 nM, respectively) against two other physiologically relevant hCA isoforms (K_i = 23.4 nM and 15 nM for hCA I and hCA II, respectively), as compared with another CA inhibitor AAZ (K_i = 250 nM, 12 nM, 25 nM, and 5.7 nM for hCA I, hCA II, hCA IX, and hCA XII, respectively). It is shown to effectively inhibit the formation of metastases by 4T1 breast cancer cells in a mouse model dose-dependently at pharmacologic concentrations of 15-45 mg/kg.

A cell permeable benzenesulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (K_i = 0.9 nM and 5.7 nM, respectively) against two other physiologically relevant hCA isoforms (K_i = 23.4 nM and 15 nM for hCA I and hCA II, respectively), as compared with another CA inhibitor AAZ (K_i = 250 nM, 12 nM, 25 nM, and 5.7 nM for hCA I, hCA II, hCA IX, and hCA XII, respectively). It is shown to effectively inhibit the formation of metastases by 4T1 breast cancer cells in a mouse model dose-dependently at pharmacologic concentrations of 15-45 mg/kg.

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Regulatory Review (Z)

Altre note

Pacchiano, F., et al. 2011. J Med Chem.54, 1896.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable