07-1491

Anti-Calcineurin pan A Antibody

from rabbit, purified by affinity chromatography

• Sinonimo/i: CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit alpha isoform, calcineurin A alpha, protein phosphatase 3 (formerly 2B), catalytic subunit, ; ; alpha isoform, protein phosphatase 3 (formerly 2B), catalytic subunit, ; ; alp
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100; 200
• Coniugato: conjugate
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Stato: liquid
• Purificato mediante: affinity chromatography
• Reattività contro le specie: human, rat, mouse
• Reattività contro le specie (prevista in base all’omologia): mammals (based on 100% sequence homology)
• tecniche: western blot: suitable
• Sequenza immunogenica: KLH-conjugated synthetic peptide corresponding to Calcineurin.
• N° accesso NCBI: NP_000935.1
• N° accesso UniProt: Q08209
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C

Descrizione

Descrizione generale

Calcineurin is a serine/threonine protein phosphatase involved in the mediation of signal tranduction in a wide variety of cellular responses. Calcineurin has been linked to Pmk1 MAP kinase and PI pathways, as well as to members of the small GTPase Rab/Ypt family and Type II myosin. Furthermore, calcineurin participates in the transduction of extracellular signals to the nucleus by dephosphorylation of members of the NFAT family of transcription factors. These linkages demonstrate calcineurin′s multifunctional capabilities in the regulation of calcium signaling.

Specificità

This antibody recognizes both the Aα and Aβ, the major catalytic subunit gene isoforms of calcineurin in most tissues; may also react with the testis form, Aγ. This antibody has very high sensitivity and specificity, which allow detection of calcineurin in tissues where expression is low, such as lymphoid tissue. Reacts with calcineurin of all mammalian species.

Immunogeno

KLH-conjugated synthetic peptide corresponding to Calcineurin.

Applicazioni

Detect Calcineurin pan A using this Anti-Calcineurin pan A Antibody validated for use in WB.

Research Category
Signaling

Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling

Qualità

Evaluated by Western Blot in Mouse brain lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected Calcineurin on 10 µg of mouse brain lysate.

Descrizione del bersaglio

~58 kDa

Linkage

Replaces: AB1695

Stato fisico

Affinity purified

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 40% gylerol. Contains no preservative.

Stoccaggio e stabilità

Store at -20°C for up to 12 months in undiluted aliquots; at this temperature the solution will
remain unfrozen.

Risultati analitici

Control
Mouse brain lysate

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable