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Merck
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Key Documents

05-726

Sigma-Aldrich

Anti-53BP1 Antibody, clone BP13

clone BP13, Upstate®, from mouse

Sinonimo/i:

Anti-53BP1, Anti-p202, Anti-p53BP1

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

Forma dell’anticorpo

purified antibody

Tipo di anticorpo

primary antibodies

Clone

BP13, monoclonal

Reattività contro le specie

human

Produttore/marchio commerciale

Upstate®

tecniche

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotipo

IgG1

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... TP53BP1(7158)

Specificità

53BP1

Immunogeno

Mix of three GST fusion proteins corresponding to residues 1-337, 338-671, and 1331-1664, respectively, of human 53BP1

Applicazioni

Detect 53BP1 with Anti-53BP1 Antibody, clone BP13 (Mouse Monoclonal Antibody), that has been shown to work in IP, WB, ICC.
Does not cross-react with mouse.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors

Qualità

routinely evaluated by immunoblot on lysates from HeLa cells

Descrizione del bersaglio

~250kDa

Stato fisico

0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
Protein G Purified

Stoccaggio e stabilità

2 years at -20°C

Note legali

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Determinazione del prezzo

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1


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Quantitative analysis of DNA-damage response factors after sequential ion microirradiation.
Christoph Greubel, Volker Hable, Guido A Drexler, Andreas Hauptner, Steffen Dietzel et al.
Radiation and Environmental Biophysics null
I M Ward et al.
The Journal of biological chemistry, 276(51), 47759-47762 (2001-10-24)
H2AX, a member of the histone H2A family, is rapidly phosphorylated in response to ionizing radiation. This phosphorylation, at an evolutionary conserved C-terminal phosphatidylinositol 3-OH-kinase-related kinase (PI3KK) motif, is thought to be critical for recognition and repair of DNA double
Telomere dysfunction in human keratinocytes elicits senescence and a novel transcription profile.
Fay Minty, Johanna K Thurlow, Paul R Harrison, E Kenneth Parkinson
Experimental Cell Research null
Guanghua Du et al.
Radiation research, 176(6), 706-715 (2011-07-30)
High-linear energy transfer (LET) ion irradiation of cell nuclei induces complex and severe DNA lesions, and foci of repair proteins are formed densely along the ion trajectory. To efficiently discriminate the densely distributed/overlapping foci along the ion trajectory, a focus
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Experimental & molecular medicine, 53(6), 1092-1108 (2021-07-01)
Senescent cells exhibit a reduced response to intrinsic and extrinsic stimuli. This diminished reaction may be explained by the disrupted transmission of nuclear signals. However, this hypothesis requires more evidence before it can be accepted as a mechanism of cellular

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