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Key Documents

05-643

Sigma-Aldrich

Anti-phospho-GSK3β (Ser9) Antibody, clone 2D3

clone 2D3, Upstate®, from mouse

Sinonimo/i:

Anti-7330414F15Rik, Anti-8430431H08Rik, Anti-C86142, Anti-GSK-3, Anti-GSK-3beta, Anti-GSK3

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

2D3, monoclonal

Reattività contro le specie

human, mouse, rat

Produttore/marchio commerciale

Upstate®

tecniche

electrophoretic mobility shift assay: suitable
western blot: suitable

Isotipo

IgG1κ

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

modifica post-traduzionali bersaglio

phosphorylation (pSer9)

Informazioni sul gene

human ... GSK3B(2932)

Specificità

GSK3beta

Immunogeno

peptide corresponding to amino acids 6-12 (RTT[pS]AE) of human GSK3beta

Applicazioni

Anti-phospho-GSK3β (Ser9) Antibody, clone 2D3 is an antibody against phospho-GSK3β (Ser9) for use in EMSA & WB.
Research Category
Signaling
Research Sub Category
PI3K, Akt, & mTOR Signaling

Qualità

routinely evaluated by immunoblot on L6 cells stimulated with IGF-1

Descrizione del bersaglio

46kDa (GSK3β) and 51kDa (GSK3α)

Linkage

Replaces: 04-1075

Stato fisico

100µg of thiophilic and size exclusion chromatography purified mouse IgG1κ in 100µL of antibody storage buffer (PBS with PEG, Sucrose, and 0.09% sodium azide) and 50% glycerol.
Format: Purified
Thiophilic adsorption chromatography

Stoccaggio e stabilità

2 years at -20°C

Note legali

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Raccomandato

Codice della classe di stoccaggio

10 - Combustible liquids


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Hui Sheng et al.
International journal of medical sciences, 10(6), 782-789 (2013-05-01)
We previously reported that the constitutional flavonoid glycosides derived from herb Epimedium (EF, composed of seven flavonoid compounds with common nuclear stem) exerted beneficial effects on the bone, including promoting bone formation and inhibiting bone marrow fat deposition. Recent in
Inhibition of cyclin-dependent kinase 5 but not of glycogen synthase kinase 3-? prevents neurite retraction and tau hyperphosphorylation caused by secretable products of human T-cell leukemia virus type I-infected lymphocytes.
Maldonado, H; Ramirez, E; Utreras, E; Pando, ME; Kettlun, AM; Chiong, M; Kulkarni et al.
Journal of Neuroscience Research null
Pei-Wen Cheng et al.
Biomedicines, 9(11) (2021-11-28)
Traumatic brain injury confers a significant and growing public health burden. It is a major environmental risk factor for dementia. Nonetheless, the mechanism by which primary mechanical injury leads to neurodegeneration and an increased risk of dementia-related diseases is unclear.
Yu-Te Lin et al.
Journal of clinical medicine, 7(10) (2018-10-12)
Recent studies have indicated that several anti-hypertensive drugs may delay the development and progression of Alzheimer's disease (AD). However, the relationships among AD, hypertension, and oxidative stress remain to be elucidated. Here, we aimed to determine whether reactive oxygen species
Adam R Cole et al.
Methods in molecular biology (Clifton, N.J.), 468, 45-65 (2008-12-23)
Glycogen synthase kinase (GSK)-3 is a key signalling intermediate in the action ofWnts. This protein kinase is ubiquitously expressed and has high inherent activity but is inhibited by activation of Wnt signalling or activation of growth factor receptor tyrosine kinases

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